人类基因组中编码肿瘤坏死因子（TNF-α）和淋巴毒素（TNF-β）的基因串联排列。 - Suppr

Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.

作者信息

Nedospasov S A, Shakhov A N, Turetskaya R L, Mett V A, Azizov M M, Georgiev G P, Korobko V G, Dobrynin V N, Filippov S A, Bystrov N S

出版信息

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:611-24. doi: 10.1101/sqb.1986.051.01.073.

DOI:10.1101/sqb.1986.051.01.073

PMID:3555974

Abstract

摘要

相似文献

Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.人类基因组中编码肿瘤坏死因子（TNF-α）和淋巴毒素（TNF-β）的基因串联排列。

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:611-24. doi: 10.1101/sqb.1986.051.01.073.

Cachectin: the dark side of tumor necrosis factor.恶病质素：肿瘤坏死因子的阴暗面。

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:625-9. doi: 10.1101/sqb.1986.051.01.074.

Tumor necrosis factors: gene structure and biological activities.肿瘤坏死因子：基因结构与生物学活性

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:597-609. doi: 10.1101/sqb.1986.051.01.072.

Conformation and biological activity of TNF-alpha and TNF-alpha analogs.肿瘤坏死因子-α（TNF-α）及其类似物的构象与生物活性

Lymphokine Res. 1986;5 Suppl 1:S133-7.

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.人肿瘤坏死因子：前体结构、表达及其与淋巴毒素的同源性。

Nature. 1984;312(5996):724-9. doi: 10.1038/312724a0.

Molecular cloning and expression in Escherichia coli of the cDNA coding for rabbit tumor necrosis factor.编码兔肿瘤坏死因子的cDNA在大肠杆菌中的分子克隆与表达。

DNA. 1986 Apr;5(2):149-56. doi: 10.1089/dna.1986.5.149.

Recombinant human tumor necrosis factor--I. Cytotoxic activity in vitro.重组人肿瘤坏死因子-I。体外细胞毒性活性。

Int J Immunopharmacol. 1986;8(3):347-55. doi: 10.1016/0192-0561(86)90117-7.

High-level expression, purification, and characterization of recombinant human tumor necrosis factor synthesized in the methylotrophic yeast Pichia pastoris.

Biochemistry. 1989 May 2;28(9):4117-25. doi: 10.1021/bi00435a074.

Improvement of cytotoxicity of tumor necrosis factor (TNF) by increase in basicity of its N-terminal region.通过增加肿瘤坏死因子（TNF）N 端区域的碱性来提高其细胞毒性。

Biochem Biophys Res Commun. 1987 Oct 29;148(2):629-35. doi: 10.1016/0006-291x(87)90923-5.

[Molecular cloning of human genes coding tumor necrosis factors: tandem arrangement of alpha- and beta-genes in a short segment (6 thousand nucleotide pairs) of human genome].[编码肿瘤坏死因子的人类基因的分子克隆：α基因和β基因在人类基因组短片段（6千个核苷酸对）中的串联排列]

Dokl Akad Nauk SSSR. 1985;285(6):1487-90.

引用本文的文献

Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice.体内肿瘤坏死因子（TNF）和淋巴毒素（LT）信号通路的冗余性：整个TNF/LT基因座失活的小鼠与单敲除小鼠的比较

Mol Cell Biol. 2002 Dec;22(24):8626-34. doi: 10.1128/MCB.22.24.8626-8634.2002.

Genetic analysis of the 3' untranslated region of the tumour necrosis factor shows a highly conserved region in rheumatoid arthritis affected and unaffected subjects.肿瘤坏死因子3'非翻译区的基因分析显示，类风湿性关节炎患者和未患病者中存在一个高度保守的区域。

J Med Genet. 1999 Mar;36(3):214-6.

A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.一种新型脂多糖诱导的调节肿瘤坏死因子α基因表达的转录因子：分子克隆、测序、特性鉴定及染色体定位

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4518-23. doi: 10.1073/pnas.96.8.4518.

TNFalpha*2 marks high risk of severe disease during Plasmodium falciparum malaria and other infections in Sri Lankans.肿瘤坏死因子α*2表明在斯里兰卡人感染恶性疟原虫和其他感染期间患严重疾病的高风险。

Clin Exp Immunol. 1999 Feb;115(2):350-5. doi: 10.1046/j.1365-2249.1999.00804.x.

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.自分泌肿瘤坏死因子（TNF）和淋巴毒素（LT）α对L929细胞中细胞对TNF/LT-α细胞毒性的敏感性具有不同的调节作用。

J Cell Biol. 1998 Dec 28;143(7):2057-65. doi: 10.1083/jcb.143.7.2057.

An intragenic polymorphism in the human tumor necrosis factor alpha (TNFA) chain-encoding gene.人类肿瘤坏死因子α（TNFA）编码基因中的一个基因内多态性。

Immunogenetics. 1996;44(4):321-2. doi: 10.1007/BF02602566.

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes.

Immunogenetics. 1993;37(6):449-54. doi: 10.1007/BF00222469.

An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.人类肿瘤坏死因子α启动子区域内的一个等位基因多态性与HLA A1、B8和DR3等位基因密切相关。

J Exp Med. 1993 Feb 1;177(2):557-60. doi: 10.1084/jem.177.2.557.

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.小鼠和人类OX40/OX40配体系统的分子特征：鉴定人类OX40配体为HTLV-1调节蛋白gp34。

EMBO J. 1994 Sep 1;13(17):3992-4001. doi: 10.1002/j.1460-2075.1994.tb06715.x.

A polymorphic variation in a putative regulation box of the TNFA promoter region.肿瘤坏死因子α（TNFA）启动子区域一个假定调控框中的多态性变异。

Immunogenetics. 1994;39(2):150-4. doi: 10.1007/BF00188619.

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Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.

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