SimSCSnTree：单细胞 DNA 测序数据模拟器。

SimSCSnTree: a simulator of single-cell DNA sequencing data.

机构信息

Department of Computer Science, Florida State University, Tallahassee, FL 32306, USA.

Department of Computer Science, Rice University, Houston, TX 77025, USA.

出版信息

Bioinformatics. 2022 May 13;38(10):2912-2914. doi: 10.1093/bioinformatics/btac169.

DOI:10.1093/bioinformatics/btac169

PMID:35561189

Abstract

SUMMARY

We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches. Data generated by the simulator can be used to benchmark tools for single-cell genomic analyses, particularly in cancer where SNVs and CNAs are ubiquitous.

AVAILABILITY AND IMPLEMENTATION

SimSCSnTree is now on BioConda and also is freely available for download at https://github.com/compbiofan/SimSCSnTree.git with detailed documentation.

摘要

我们报告了一种新的单细胞 DNA 序列模拟器 SimSCSnTree，它可以生成细胞进化树，并沿着分支进化单核苷酸变体 (SNV) 和拷贝数异常 (CNA)。模拟器生成的数据可用于基准单细胞基因组分析工具，特别是在 SNV 和 CNA 普遍存在的癌症中。