年轻女性更容易受到炎症的影响：衰老在炎症和抑郁症状中的作用的纵向研究。
Younger women are more susceptible to inflammation: A longitudinal examination of the role of aging in inflammation and depressive symptoms.
机构信息
Department of Psychological Science, School of Social Ecology, University of California, Irvine, Irvine, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Development, University of California Los Angeles, Los Angeles, CA, USA; Institute for Interdisciplinary Salivary Bioscience, School of Social Ecology, University of California Irvine, Irvine, CA, USA.
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Development, University of California Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
出版信息
J Affect Disord. 2022 Aug 1;310:328-336. doi: 10.1016/j.jad.2022.05.019. Epub 2022 May 11.
BACKGROUND
The degree to which effects of inflammation on mood and behavior vary across the lifespan remains relatively unexplored despite well-established, age-related alterations in both the immune and central nervous systems. Further, the implications of this developmental process within different symptom domains warrants careful consideration.
METHODS
Women diagnosed with breast cancer (n = 188; ages 27-89) provided blood samples and reported depressive symptoms prior to adjuvant treatment, at the end of adjuvant treatment, and 6-, 12-, and 18-months after completing adjuvant treatment via the CES-D. Blood was assayed for C-reactive Protein (CRP) and interleukin (IL)-6. We used mixed linear effect models to estimate within- and between-person effects of CRP or IL-6 on 4 domains of depressive symptoms: depressed affect, low positive affect, somatic complaints, and interpersonal problems.
RESULTS
High average inflammation was associated with elevated somatic complaints (CRP p = .009, IL-6: p = .05), interpersonal problems (CRP p = .002, IL-6 p < .001), and positive affect (IL-6 p = .03), but only among the youngest women in the sample (age 50 or younger). Younger women also reported more depressed affect at assessments when inflammation was higher (CRP p = .045, IL-6 p = .09).
CONCLUSIONS
The association between inflammation and specific depressive symptoms is dynamic and varies across the lifespan, which may help clarify apparent inconsistencies in the extant literature as well as inform more precise interventions targeting this pathway.
背景
尽管免疫系统和中枢神经系统都存在与年龄相关的改变，但炎症对情绪和行为的影响在整个生命周期中的程度仍相对未知。此外，在不同症状领域内，这种发展过程的意义需要仔细考虑。
方法
患有乳腺癌的女性（n=188；年龄 27-89 岁）在辅助治疗前、辅助治疗结束时以及完成辅助治疗后的 6、12 和 18 个月通过 CES-D 报告抑郁症状并提供血液样本。血液样本用于检测 C 反应蛋白（CRP）和白细胞介素（IL）-6。我们使用混合线性效应模型来估计 CRP 或 IL-6 对 4 个抑郁症状领域的个体内和个体间影响：抑郁情绪、低正性情绪、躯体症状和人际问题。
结果
高平均炎症与躯体症状升高有关（CRP p=0.009，IL-6：p=0.05）、人际问题（CRP p=0.002，IL-6 p<0.001）和正性情绪（IL-6 p=0.03），但仅在样本中最年轻的女性中（年龄在 50 岁或以下）。炎症水平较高时，年轻女性在评估中报告的抑郁情绪更多（CRP p=0.045，IL-6 p=0.09）。
结论
炎症与特定抑郁症状之间的关联是动态的，并且在整个生命周期中都有所不同，这可能有助于澄清现有文献中的明显不一致，并为针对该途径的更精确干预提供信息。
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