Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland.
Department of Infectious, Tropical Diseases and Immune Deficiency, Pomeranian Medical University in Szczecin, 71-455 Szczecin, Poland.
Int J Mol Sci. 2022 Apr 20;23(9):4545. doi: 10.3390/ijms23094545.
In the beginning of the third year of the fight against COVID-19, the virus remains at least still one step ahead in the pandemic "war". The key reasons are evolving lineages and mutations, resulting in an increase of transmissibility and ability to evade immune system. However, from the immunologic point of view, the cytokine storm (CS) remains a poorly understood and difficult to combat culprit of the extended number of in-hospital admissions and deaths. It is not fully clear whether the cytokine release is a harmful result of suppression of the immune system or a positive reaction necessary to clear the virus. To develop methods of appropriate treatment and therefore decrease the mortality of the so-called COVID-19-CS, we need to look deeply inside its pathogenesis, which is the purpose of this review.
在抗击 COVID-19 的第三年伊始，该病毒在这场大流行“战争”中至少仍领先一步。关键原因是不断进化的谱系和突变，导致其传染性和逃避免疫系统能力增强。然而，从免疫学角度来看，细胞因子风暴（CS）仍然是导致住院人数和死亡人数增加的一个尚未完全了解且难以应对的罪魁祸首。目前尚不完全清楚细胞因子释放是免疫系统抑制的有害结果，还是清除病毒所必需的积极反应。为了开发适当的治疗方法，从而降低所谓 COVID-19-CS 的死亡率，我们需要深入研究其发病机制，这正是本次综述的目的。
