Department of Plant Biosecurity and MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, P. R. China.
State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
ACS Appl Mater Interfaces. 2021 Aug 4;13(30):36350-36360. doi: 10.1021/acsami.1c09887. Epub 2021 Jul 20.
The application of botanical pesticides is a good choice in organic agriculture. However, most botanical pesticides have limitations of slow action and short persistence for pest and disease management, which constrain their further application. With the objective of exploring a green pesticide for controlling strawberry pests and diseases simultaneously, a star polymer (SPc) with a low production cost was synthesized as a pesticide nanocarrier through simple reactions. The SPc complexed with osthole quickly through electrostatic interaction and hydrophobic association, which decreased the particle size of osthole down to the nanoscale (17.66 nm). With the help of SPc, more nano-sized osthole was delivered into cytoplasm through endocytosis, leading to the enhanced cytotoxicity against insect cells. As a green botanical pesticide, the control efficacy of the osthole/SPc complex was improved against main strawberry pests (green peach aphid and two-spotted spider mite) and disease (powdery mildew), which fulfilled the need of both pest and disease management in sustainable production of strawberry. Meanwhile, the introduction of SPc not only improved plant-uptake but also decreased the residue of osthole due to the higher degradation rate. Furthermore, the application of the osthole/SPc complex exhibited no influence on the strawberry fruit quality and nontarget predators. To our knowledge, it is the first success to control plant pests and diseases simultaneously for sustainable agriculture by only one pesticidal formulation based on nanoparticle-delivered botanical pesticides.
植物源农药的应用是有机农业中防治病虫害的一种较好选择。然而，大多数植物源农药在防治病虫害时，作用缓慢且持效期短，这限制了它们的进一步应用。为了探索一种同时防治草莓病虫害的绿色农药，我们通过简单的反应合成了一种低成本的星型聚合物（SPc）作为农药纳米载体。SPc 与蛇床子素通过静电相互作用和疏水缔合快速结合，将蛇床子素的粒径减小到纳米级（17.66nm）。在 SPc 的帮助下，更多纳米级的蛇床子素通过内吞作用被递送到细胞质中，导致对昆虫细胞的细胞毒性增强。作为一种绿色植物源农药，蛇床子素/SPc 复合物对主要草莓害虫（桃蚜和二斑叶螨）和病害（白粉病）的防治效果得到了提高，满足了草莓可持续生产中病虫害综合治理的需要。同时，由于 SPc 具有较高的降解率，不仅提高了植物的吸收，还降低了蛇床子素的残留。此外，蛇床子素/SPc 复合物的应用对草莓果实品质和非靶标捕食者没有影响。据我们所知，这是首次成功地通过基于纳米颗粒递送的植物源农药的单一农药配方同时防治植物病虫害，实现可持续农业的目标。
