氢氧化钙联合质子泵抑制剂对……的抗菌效果评估
Evaluation of Antimicrobial Efficacy of Calcium Hydroxide along with Proton Pump Inhibitor against .
作者信息
Divakar Namitha, Mohan Sunil Paramel, Pulyodan Manoj Kumar, Tom Arun, Karukayil Deepthi, Somasundaram Maya
机构信息
Department of Conservative Dentistry and Endodontics, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.
Department of Oral Pathology and Microbiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.
出版信息
J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S352-S354. doi: 10.4103/jpbs.JPBS_104_20. Epub 2020 Aug 28.
AIM
The aim of this study was to evaluate the efficacy of pantoprazole, a proton pump inhibitor, alone, and in combination with calcium hydroxide against , a star survivor in endodontic pathology.
MATERIALS AND METHODS
Teeth were inoculated with strains MTCC 439 and were divided into groups. Group 1 used saline as the negative control, Group 2 used calcium hydroxide, Group 3 used pantoprazole alone, and Group 4 used calcium hydroxide along with pantoprazole. They were incubated and dentine harvesting was performed. Colonies were counted using a digital counting machine. Data were statistically analyzed.
RESULTS
Group 4 was found to be the most effective against the pathogen.
DISCUSSION
This study indicates that the association of calcium hydroxide with the proton pump inhibitor pantoprazole can be successfully used as an intracanal medicament against .
目的
本研究旨在评估质子泵抑制剂泮托拉唑单独使用以及与氢氧化钙联合使用对牙髓病学中一种顽强存活菌的疗效。
材料与方法
用菌株MTCC 439接种牙齿并分组。第1组用生理盐水作为阴性对照，第2组用氢氧化钙，第3组单独用泮托拉唑，第4组用氢氧化钙与泮托拉唑联合使用。将它们进行培养并采集牙本质。使用数字计数器对菌落进行计数。对数据进行统计学分析。
结果
发现第4组对该病原体最有效。
讨论
本研究表明，氢氧化钙与质子泵抑制剂泮托拉唑联合可成功用作根管内药物来对抗该菌。
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