Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation, Hualien 970, Taiwan.
Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation, Hualien 970, Taiwan.
Int J Environ Res Public Health. 2022 May 1;19(9):5495. doi: 10.3390/ijerph19095495.
Two to five percent of infants and children experience febrile seizures (FS). Breastfeeding is beneficial to the health of mothers and children. Nevertheless, the benefits of breastfeeding in reducing FS remain unclear; thus, the present study aimed to evaluate this association. The case group was selected from 2010 to 2019, and the selected population was children younger than 5 years (i.e., children born from 2005−2019). The control group was selected from newborn infants at our hospital born between 2005 and 2019. Finally, 55 children with FS and 110 children in the control group were recruited. The results show longer breastfeeding duration is associated with an increased risk of FS (adjusted odds ratio: 1.06, 95% confidence interval: 1.01−1.11, p = 0.028). When comparing cases of FS with the control group, the percentage of inclusive breastfeeding over 12 months (32.7% vs. 9.1%, p = 0.017) and longer duration of exclusive breastfeeding were higher (10.86 ± 11.82 vs. 5.40 ± 7.17 months, p < 0.001). However, the comparison of the prevalence of FS between the different breastfeeding duration groups did not reach statistical significance. In conclusion, our study showed that a longer breastfeeding duration was associated with a higher risk of FS. Future large-scale studies evaluating the association between breastfeeding duration and febrile seizures are needed.
2%至 5%的婴儿和儿童会出现热性惊厥（FS）。母乳喂养对母婴健康有益。然而，母乳喂养在减少 FS 方面的益处尚不清楚；因此，本研究旨在评估这种关联。病例组选自 2010 年至 2019 年，所选人群为 5 岁以下儿童（即 2005-2019 年出生的儿童）。对照组选自我院 2005 年至 2019 年出生的新生儿。最终，招募了 55 名 FS 患儿和 110 名对照组患儿。结果表明，母乳喂养时间越长，FS 的风险越高（调整后的比值比：1.06，95%置信区间：1.01-1.11，p=0.028）。与对照组相比，FS 病例组中 12 个月以上的混合喂养比例（32.7%比 9.1%，p=0.017）和纯母乳喂养持续时间更长（10.86±11.82 比 5.40±7.17 个月，p<0.001）。然而，不同母乳喂养持续时间组 FS 患病率的比较没有达到统计学意义。总之，本研究表明，母乳喂养时间越长，FS 的风险越高。需要进一步开展大规模研究评估母乳喂养持续时间与热性惊厥之间的关联。
