Blanco Mariola, Collazo-Lorduy Ana, Yanguas-Casás Natalia, Calvo Virginia, Provencio Mariano
Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, 28222 Madrid, Spain.
Lymphoma Research Group, Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, CIBERFES, 28222 Madrid, Spain.
Cancers (Basel). 2022 Apr 26;14(9):2158. doi: 10.3390/cancers14092158.
Follicular lymphomas (FL) are neoplasms that resemble normal germinal center (GC) B-cells. Normal GC and neoplastic follicles contain non-neoplastic cells such as T-cells, follicular dendritic cells, cancer associated fibroblasts, and macrophages, which define the tumor microenvironment (TME), which itself is an essential factor in tumor cell survival. The main characteristics of the TME in FL are an increased number of follicular regulatory T-cells (T) and follicular helper T-cells (T), M2-polarization of macrophages, and the development of a nodular network by stromal cells that creates a suitable niche for tumor growth. All of them play important roles in tumor angiogenesis, inhibition of apoptosis, and immune evasion, which are key factors in tumor progression and transformation risk. Based on these findings, novel therapies have been developed to target specific mutations present in the TME cells, restore immune suppression, and modulate TME.
滤泡性淋巴瘤（FL）是一种类似于正常生发中心（GC）B细胞的肿瘤。正常的GC和肿瘤性滤泡含有非肿瘤细胞，如T细胞、滤泡树突状细胞、癌症相关成纤维细胞和巨噬细胞，这些细胞构成了肿瘤微环境（TME），而TME本身是肿瘤细胞存活的一个重要因素。FL中TME的主要特征是滤泡调节性T细胞（T）和滤泡辅助性T细胞（T）数量增加、巨噬细胞的M2极化以及基质细胞形成结节状网络，从而为肿瘤生长创造合适的微环境。它们在肿瘤血管生成、抑制细胞凋亡和免疫逃逸中都发挥着重要作用，而这些都是肿瘤进展和转化风险的关键因素。基于这些发现，已经开发出了针对TME细胞中特定突变的新型疗法，以恢复免疫抑制并调节TME。
