Barcelos Kênia Alves, Mendonça Carolina Rodrigues, Noll Matias, Botelho Ana Flávia, Francischini Cristiane Raquel Dias, Silva Marco Augusto Machado
Postgraduate Program of Animal Science, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiás 74690-900, Brazil.
Faculty of Medicine, Universidade de Rio Verde-UniRV, Rio de Janeiro 75901-970, Brazil.
Cancers (Basel). 2022 Apr 26;14(9):2165. doi: 10.3390/cancers14092165.
Breast cancer is one of the most common neoplasms among women. Anticancer strategies using natural formulations and phytotherapies are promising antitumor treatment alternatives. This review assesses the antitumor effects of curcumin on breast cancer reported in preclinical in vitro and in vivo animal models. We used five databases to search for preclinical studies published up to May 2021. The assessments included the effects of curcumin on the proliferation, viability, and apoptosis of breast cancer cell lineages and on tumor volume. In total, 60 articles met the inclusion criteria. Curcumin administered at different concentrations and via different routes of administration inhibited proliferation, decreased viability, and induced apoptosis in human and animal breast cancer cells. Nanoparticle formulations of curcumin administered orally, via implant, and intraperitoneally reduced the tumor volume of human and murine mammary cells in vivo. Moreover, curcumin nanoformulations exert positive effects on tumor growth inhibition in animal models of breast cancer. Further randomized clinical trials are warranted to assess the efficacy and safety of curcumin formulations for clinical use.
乳腺癌是女性中最常见的肿瘤之一。使用天然制剂和植物疗法的抗癌策略是很有前景的抗肿瘤治疗选择。本综述评估了姜黄素在临床前体外和体内动物模型中对乳腺癌的抗肿瘤作用。我们使用了五个数据库来搜索截至2021年5月发表的临床前研究。评估内容包括姜黄素对乳腺癌细胞系的增殖、活力和凋亡以及肿瘤体积的影响。共有60篇文章符合纳入标准。不同浓度和给药途径的姜黄素抑制了人和动物乳腺癌细胞的增殖，降低了活力，并诱导了凋亡。口服、植入和腹腔注射姜黄素纳米颗粒制剂可在体内减小人和鼠乳腺细胞的肿瘤体积。此外，姜黄素纳米制剂对乳腺癌动物模型的肿瘤生长抑制具有积极作用。有必要进行进一步的随机临床试验，以评估姜黄素制剂临床应用的疗效和安全性。
