Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia.
Int J Mol Sci. 2022 Feb 15;23(4):2144. doi: 10.3390/ijms23042144.
Female breast cancer is the world's most prevalent cancer in 2020. Chemotherapy still remains a backbone in breast cancer therapy and is crucial in advanced and metastatic breast cancer treatment. The clinical efficiency of chemotherapy regimens is limited due to tumor heterogeneity, chemoresistance, and side effects. Chemotherapeutic drug combinations with natural products hold great promise for enhancing their anticancer efficacy. Curcumin is an ideal chemopreventive and chemotherapy agent owning to its multitargeting function on various regulatory molecules, key signaling pathways, and pharmacological safety. This review aimed to elucidate the potential role of curcumin in enhancing the efficacy of doxorubicin, paclitaxel, 5-fluorouracil, and cisplatin via combinational therapy. Additionally, the molecular mechanisms underlying the chemosensitizing activity of these combinations have been addressed. Overall, based on the promising therapeutic potential of curcumin in combination with conventional chemotherapy drugs, curcumin is of considerable value to develop as an adjunct for combination chemotherapy with current drugs to treat breast cancer. Furthermore, this topic may provide the frameworks for the future research direction of curcumin-chemotherapy combination studies and may benefit in the development of a novel therapeutic strategy to maximize the clinical efficacy of anticancer drugs while minimizing their side effects in the future breast cancer treatment.
2020 年，女性乳腺癌是全球最普遍的癌症。化疗仍然是乳腺癌治疗的基础，在晚期和转移性乳腺癌的治疗中至关重要。由于肿瘤异质性、化疗耐药性和副作用，化疗方案的临床疗效有限。天然产物与化疗药物的联合具有增强其抗癌疗效的巨大潜力。姜黄素由于其对各种调节分子、关键信号通路和药理学安全性的多靶向作用，是一种理想的化学预防和化疗药物。本综述旨在阐明姜黄素通过联合治疗增强多柔比星、紫杉醇、5-氟尿嘧啶和顺铂疗效的潜在作用。此外，还探讨了这些组合的化学增敏活性的分子机制。总的来说，基于姜黄素与传统化疗药物联合的有前途的治疗潜力，姜黄素具有相当的价值，可以与当前药物联合开发作为辅助联合化疗，用于治疗乳腺癌。此外，这一主题可能为姜黄素-化疗联合研究的未来研究方向提供框架，并可能有助于制定一种新的治疗策略，以最大限度地提高抗癌药物的临床疗效，同时最大限度地减少未来乳腺癌治疗中的副作用。
