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相位角是比主观整体评估更能预测住院结局的指标:来自前瞻性德绍医院营养不良研究的结果。

Phase Angle Is a Stronger Predictor of Hospital Outcome than Subjective Global Assessment-Results from the Prospective Dessau Hospital Malnutrition Study.

机构信息

Department of Internal Medicine, Dessau Community General Hospital, Auenweg 38, 06847 Dessau-Rosslau, Germany.

Medical University Vienna, Center for Medical Statistics, Informatics and Intelligent Systems, CEMSIIS, Spitalgasse 23, 1090 Vienna, Austria.

出版信息

Nutrients. 2022 Apr 24;14(9):1780. doi: 10.3390/nu14091780.

Abstract

This prospective cohort study of 16,943 consecutive patients compared phase angle (PhA, foot-to-hand at 50 kHz) and subjective global assessment (SGA) to predict outcomes length of hospital stay (LOS) and in-hospital mortality in patients at risk of malnutrition (NRS-2002 ≥ 3). In 1505 patients, the independent effects on LOS were determined by competing risk analysis and on mortality by logistic regression. In model I, including influence factors age, sex, BMI, and diagnoses, malnourished (SGA B and C) patients had a lower chance for a regular discharge (HR 0.74; 95%CI 0.69−0.79) and an increased risk of mortality (OR 2.87; 95%CI 1.38−5.94). The association of SGA and outcomes regular discharge and mortality was completely abrogated when PhA was added (model II). Low PhA reduced the chance of a regular discharge by 53% in patients with a PhA ≤ 3° (HR 0.47; 95%CI 0.39−0.56) as compared to PhA > 5°. Mortality was reduced by 56% for each 1° of PhA (OR 0.44; 95%CI 0.32−0.61). Even when CRP was added in model III, PhA ≤ 3° was associated with a 41% lower chance for a regular discharge (HR 0.59; 95%CI 0.48−0.72). In patients at risk of malnutrition, the objective measure PhA was a stronger predictor of LOS and mortality than SGA.

摘要

这项前瞻性队列研究纳入了 16943 例连续患者,比较了相位角(50kHz 时的足到手)和主观整体评估(SGA),以预测有营养不良风险的患者(NRS-2002≥3)的住院结局(住院时间(LOS)和院内死亡率。在 1505 例患者中,通过竞争风险分析确定 LOS 的独立影响因素,并通过 logistic 回归确定死亡率的影响因素。在模型 I 中,包括影响因素年龄、性别、BMI 和诊断,营养不良(SGA B 和 C)患者正常出院的机会较低(HR 0.74;95%CI 0.69−0.79),死亡风险增加(OR 2.87;95%CI 1.38−5.94)。当添加相位角(模型 II)时,SGA 与结局正常出院和死亡率的相关性完全消除。与相位角>5°的患者相比,相位角≤3°的患者正常出院的机会降低了 53%(HR 0.47;95%CI 0.39−0.56)。每增加 1°相位角,死亡率降低 56%(OR 0.44;95%CI 0.32−0.61)。即使在模型 III 中添加 CRP,相位角≤3°与正常出院的机会降低 41%相关(HR 0.59;95%CI 0.48−0.72)。在有营养不良风险的患者中,客观测量相位角是 LOS 和死亡率的更强预测指标,优于 SGA。

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