TNO (Netherlands Organisation for Applied Scientific Research), Microbiology and Systems Biology, 3704 HE Zeist, The Netherlands.
D&R Institute of Pathology, Medical University of Graz, 8010 Graz, Austria.
Nutrients. 2022 Apr 29;14(9):1881. doi: 10.3390/nu14091881.
Studies indicate that the intestinal microbiota influences general metabolic processes in humans, thereby modulating the risk of chronic diseases such as type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietary factors are also directly related to chronic disease risk, and they affect the composition and function of the gut microbiota. Still, detailed knowledge on the relation between diet, the microbiota, and chronic disease risk is limited. The overarching aim of the HDHL-INTIMIC (INtesTInal MICrobiomics) knowledge platform is to foster studies on the microbiota, nutrition, and health by assembling available knowledge of the microbiota and of the other aspects (e.g., food science and metabolomics) that are relevant in the context of microbiome research. The goal is to make this information findable, accessible, interoperable, and reusable (FAIR) to the scientific community, and to share information with the various stakeholders. Through these efforts a network of transnational and multidisciplinary collaboration has emerged, which has contributed to further develop and increase the impact of microbiome research in human health. The roles of microbiota in early infancy, during ageing, and in subclinical and clinically manifested disease are identified as urgent areas of research in this knowledge platform.
研究表明，肠道微生物群会影响人类的一般代谢过程，从而调节 2 型糖尿病、过敏、心血管疾病和结直肠癌（CRC）等慢性病的风险。饮食因素也与慢性病风险直接相关，它们会影响肠道微生物群的组成和功能。然而，关于饮食、微生物群和慢性病风险之间的关系的详细知识仍然有限。HDHL-INTIMIC（肠道微生物组学）知识平台的总体目标是通过汇集有关微生物群和其他方面（例如食品科学和代谢组学）的可用知识来促进有关微生物群、营养和健康的研究，这些知识在微生物组研究背景下是相关的。目标是使这些信息对科学界具有可发现性、可访问性、互操作性和可重用性（FAIR），并与各个利益相关者共享信息。通过这些努力，形成了一个跨国和多学科合作的网络，这有助于进一步发展和增加微生物组研究在人类健康中的影响力。该知识平台确定了微生物群在婴儿早期、衰老过程以及亚临床和临床表现疾病中的作用，作为紧迫的研究领域。
