Fernández-Araque Ana, Verde Zoraida, Torres-Ortega Clara, Sainz-Gil Maria, Velasco-Gonzalez Veronica, González-Bernal Jerónimo Javier, Mielgo-Ayuso Juan
Research Group Pharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology, Department of Nursing, Faculty of Health Sciences, University of Valladolid, Campus of Soria, 42003 Soria, Spain.
Department of Nursing, Faculty of Health Sciences, University of Valladolid, 42005 Soria, Spain.
J Clin Med. 2022 Apr 27;11(9):2462. doi: 10.3390/jcm11092462.
In recent years, antioxidant supplements have become popular to counteract the effects of oxidative stress in fibromyalgia and one of its most distressing symptoms, pain. The aim of this systematic review was to summarize the effects of antioxidant supplementation on pain levels perceived by patients diagnosed with fibromyalgia. The words used respected the medical search terms related to our objective including antioxidants, fibromyalgia, pain, and supplementation. Seventeen relevant articles were identified within Medline (PubMed), Scopus, Web of Science (WOS), the Cochrane Database of Systematic Review, and the Cochrane Central Register of Controlled Trials. This review found that antioxidant supplementation is efficient in reducing pain in nine of the studies reviewed. Studies with a duration of supplementation of at least 6 weeks showed a benefit on pain perception in 80% of the patients included in these studies. The benefits shown by vitamins and coenzyme Q10 are remarkable. Further research is needed to identify the effects of other types of antioxidants, such as extra virgin olive oil and turmeric. More homogeneous interventions in terms of antioxidant doses administered and duration would allow the effects on pain to be addressed more comprehensively.
近年来，抗氧化剂补充剂已成为对抗纤维肌痛及其最令人痛苦的症状之一——疼痛中氧化应激影响的常用方法。本系统评价的目的是总结抗氧化剂补充剂对被诊断为纤维肌痛患者疼痛程度的影响。所使用的词汇遵循与我们目标相关的医学检索词，包括抗氧化剂、纤维肌痛、疼痛和补充剂。在医学文献数据库（PubMed）、Scopus、科学引文索引（WOS）、Cochrane系统评价数据库和Cochrane对照试验中心注册库中识别出17篇相关文章。该评价发现，在所审查的9项研究中，抗氧化剂补充剂在减轻疼痛方面是有效的。补充时间至少为6周的研究表明，这些研究中80%的患者在疼痛感知方面有改善。维生素和辅酶Q10显示出的益处显著。需要进一步研究以确定其他类型抗氧化剂的作用，如特级初榨橄榄油和姜黄。在抗氧化剂剂量和补充时间方面进行更统一的干预将有助于更全面地探讨其对疼痛的影响。
