Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Cortex. 2022 Aug;153:235-256. doi: 10.1016/j.cortex.2022.03.019. Epub 2022 Apr 19.
The inferior frontal sulcus is conceptualized as the landmark delineating ventro-from dorsolateral prefrontal cortex. Functional imaging studies report activations within the sulcus during tasks addressing cognitive control and verbal working memory, while their microstructural correlates are not well defined. Existing microstructural maps, e.g., Brodmann's map, do not distinguish separate areas within the sulcus. We identified six new areas in the inferior frontal sulcus and its junction to the precentral sulcus, ifs1-4, ifj1-ifj2, by combined cytoarchitectonic analysis and receptor autoradiography. A hierarchical cluster analysis of receptor densities of these and neighbouring prefrontal areas revealed that they form a distinct cluster within the prefrontal cortex. Major interhemispheric differences were found in both cyto- and receptorarchitecture. The function of cytoarchitectonically identified areas was explored by comparing probabilistic maps of the areas in stereotaxic space with their functions and co-activation patterns as analysed by means of a coordinate-based meta-analysis. We found a bilateral involvement in working memory, as well as a lateralization of different language-related processes to the left hemisphere, and of music processing and attention to the right-hemispheric areas. Particularly ifj2 might act as a functional hub between the networks. The cytoarchitectonic maps and receptor densities provide a powerful tool to further elucidate the function of these areas. The maps are available through the Human Brain Atlas of the Human Brain Project and serve in combination with the information on the cyto- and receptor architecture of the areas as a resource for brain models and simulations.
下额前回被概念化为区分腹侧和背外侧前额叶皮质的地标。功能成像研究报告在涉及认知控制和言语工作记忆的任务中，在该脑回内有激活，而其微观结构的相关性尚不清楚。现有的微观结构图谱，如布罗德曼图谱，并不区分脑回内的单独区域。我们通过联合细胞构筑分析和受体放射性自显影术，在额下回及其与中央前回的交界处识别出额下回及其与中央前回的交界处的六个新区域（ifs1-4、ifj1-ifj2）。对这些和相邻前额叶区域的受体密度进行层次聚类分析表明，它们在前额叶皮质内形成一个独特的簇。在细胞构筑和受体结构中都发现了明显的大脑两半球间差异。通过将这些区域在立体定向空间中的概率图谱与其通过基于坐标的荟萃分析分析的功能和共同激活模式进行比较，探索了细胞构筑学鉴定的区域的功能。我们发现双侧参与工作记忆，以及不同语言相关过程的偏侧化到左半球，以及音乐处理和注意力到右半球区域。特别是 ifj2 可能作为网络之间的功能枢纽。细胞构筑图谱和受体密度提供了一个强大的工具，以进一步阐明这些区域的功能。图谱可通过人类大脑项目的人类大脑图谱获得，并与有关这些区域的细胞构筑和受体结构的信息结合使用，作为大脑模型和模拟的资源。
