Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
Front Public Health. 2022 Apr 28;10:882586. doi: 10.3389/fpubh.2022.882586. eCollection 2022.
Globally, prostate cancer is rated the second most common cancer and the sixth leading cause of death. In South Africa, it is ranked as leading cancer among men. This study describes prostate cancer patterns and trends in the rural Eastern Cape Province population.
Secondary data were used from which a sample of 723 prostate cancer (C61) patients was extracted from the database into STATA version 14.0 for descriptive analysis. A direct standardization method was used to estimate age-specific and age-standardized incidence rates. Keyfitz method was used to calculate the standard error and confidence interval, whereas the Joinpoint program the annual percentage change.
The mean age was 64 years, with a standard deviation of 9.9. Trends in prostate cancer incidence increased significantly ( = 0.026) from 7.4% in 2010 to 12.6% in 2017. Incidence rates varied across the region, with the lowest of 4.5 per 100,000 in 1998 to the highest of 21.4 per 100,000 in 2017 period. Lusikisiki had the highest incidence rates of 53.4 per 100,000 population (95% CI 0.8-61.4), while Centane with 21.7 per 100,000 (95% CI 2.3-27.6) rated the second. Other magisterial areas showed a constant increase ( > 0.05) throughout the observation period except for Idutywa and Willowvale, with no apparent increase. Conversely, in Butterworth, incidence rates decreased from 15.2 per 100 000 (95% CI 8.6-21.9) to 11.5 per 100,000 (95% CI 6.2-16.7).
As experienced globally and regionally, prostate cancer has become a public health concern in this population. Incidence variations across the surveillance area in the Eastern Cape were noted with hotspots.
在全球范围内，前列腺癌是第二大常见癌症，也是第六大死亡原因。在南非，它是男性中最常见的癌症。本研究描述了东开普省农村地区前列腺癌的发病模式和趋势。
使用二次数据，从数据库中提取了 723 名前列腺癌（C61）患者的样本，输入 STATA 版本 14.0 进行描述性分析。采用直接标准化法估计年龄别和年龄标准化发病率。Keyfitz 法计算标准误差和置信区间，而 Joinpoint 程序计算年变化百分比。
平均年龄为 64 岁，标准差为 9.9。前列腺癌发病率呈显著上升趋势（ = 0.026），从 2010 年的 7.4%上升到 2017 年的 12.6%。发病率在该地区存在差异，最低为 1998 年的 4.5/100,000，最高为 2017 年的 21.4/100,000。卢西基西基的发病率最高，为 53.4/100,000 人口（95%CI 0.8-61.4），而森坦的发病率为 21.7/100,000（95%CI 2.3-27.6），位居第二。其他治安区在整个观察期间呈持续上升趋势（>0.05），除伊杜瓦和威洛维尔外，无明显上升趋势。相反，在巴特沃斯，发病率从 15.2/100,000（95%CI 8.6-21.9）降至 11.5/100,000（95%CI 6.2-16.7）。
与全球和区域经验一致，前列腺癌已成为该人群的公共卫生关注点。在东开普省的监测区域内，发病率存在差异，并有热点地区。
