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在水中一步法制备适用于磁共振成像温度测量的高度稳定的铜锌铁氧体纳米颗粒。

One-Step Preparation of Highly Stable Copper-Zinc Ferrite Nanoparticles in Water Suitable for MRI Thermometry.

作者信息

Lachowicz Dorota, Stroud John, Hankiewicz Janusz H, Gassen River, Kmita Angelika, Stepień Joanna, Celinski Zbigniew, Sikora Marcin, Zukrowski Jan, Gajewska Marta, Przybylski Marek

机构信息

Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, 30-059 Krakow, Poland.

Center for the Biofrontiers Institute, University of Colorado Colorado Springs, 1420 Austin Bluffs Pkway, Colorado Springs, Colorado 80918, United States.

出版信息

Chem Mater. 2022 May 10;34(9):4001-4018. doi: 10.1021/acs.chemmater.2c00079. Epub 2022 Apr 20.

DOI:10.1021/acs.chemmater.2c00079
PMID:35573108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9097161/
Abstract

Superparamagnetic ferrite nanoparticles coated with a polymer layer are widely used for biomedical applications. The objective of this work is to design nanoparticles as a magnetic resonance imaging (MRI) temperature-sensitive contrast agent. Copper-zinc ferrite nanoparticles coated with a poly(ethylene glycol) (PEG) layer are synthesized using a one-step thermal decomposition method in a polymer matrix. The resulting nanoparticles are stable in water and biocompatible. Using Mössbauer spectroscopy and magnetometry, it was determined that the grown nanoparticles exhibit superparamagnetic properties. Embedding these particles into an agarose gel resulted in significant modification of water proton relaxation times , , and * determined by nuclear magnetic resonance measurements. The results of the spin-echo -weighted MR images of an aqueous phantom with embedded CuZnFeO nanoparticles in the presence of a strong temperature gradient show a strong correlation between the temperature and the image intensity. The presented results support the hypothesis that CuZn ferrite nanoparticles can be used as a contrast agent for MRI thermometry.

摘要

涂覆有聚合物层的超顺磁性铁氧体纳米颗粒被广泛用于生物医学应用。这项工作的目的是设计纳米颗粒作为磁共振成像（MRI）温度敏感造影剂。在聚合物基质中使用一步热分解法合成涂覆有聚乙二醇（PEG）层的铜锌铁氧体纳米颗粒。所得纳米颗粒在水中稳定且具有生物相容性。使用穆斯堡尔光谱和磁力测量法，确定生长的纳米颗粒表现出超顺磁性。将这些颗粒嵌入琼脂糖凝胶中导致通过核磁共振测量确定的水质子弛豫时间、和发生了显著改变。在存在强温度梯度的情况下，对含有嵌入CuZnFeO纳米颗粒的水性体模的自旋回波加权MR图像的结果表明温度与图像强度之间存在强相关性。所呈现的结果支持了铜锌铁氧体纳米颗粒可作为MRI测温造影剂的假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/26994129e12f/cm2c00079_0015.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/26994129e12f/cm2c00079_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/f5d8b53a2928/cm2c00079_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/956ee770f0ad/cm2c00079_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/a9f342b8a314/cm2c00079_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/900004c94a0f/cm2c00079_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/32f5b66088e2/cm2c00079_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/aa35849f38d8/cm2c00079_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/bae438bd6352/cm2c00079_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/2184f41c0a7c/cm2c00079_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/67dfa9f8d72c/cm2c00079_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/6ed48e8e09f6/cm2c00079_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/0a38a93833ee/cm2c00079_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/080b86c06a49/cm2c00079_0013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0282/9097161/26994129e12f/cm2c00079_0015.jpg

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