Briones Andrea, Martos Gustavo, Bedu Magali, Choteau Tiphaine, Josephs Ralf D, Wielgosz Robert I, Ryadnov Maxim G
National Physical Laboratory, Hampton Road, Teddington TW11 0LW, UK.
Bureau International des Poids et Mesures, Pavillon de Breteuil, 92312 Sèvres, France.
iScience. 2022 Apr 25;25(5):104294. doi: 10.1016/j.isci.2022.104294. eCollection 2022 May 20.
A reference material for virus-like particles traceable to the International System of Units (Système International d'Unités - the SI) is reported. The material addresses the need for developing reference standards to benchmark virus-like gene delivery systems and help harmonize measurement approaches for characterization and testing. The material is a major component of synthetic polypeptide virus-like particles produced by the state-of-the-art synthetic and analytical chemistry methods used to generate gene delivery systems. The purity profile of the material is evaluated to the highest metrological order demonstrating traceability to the SI. The material adds to the emerging toolkit of reference standards for quantitative biology.
报道了一种可溯源至国际单位制（国际单位制——SI）的病毒样颗粒参考物质。该物质满足了开发参考标准以对病毒样基因递送系统进行基准测试并有助于统一表征和测试测量方法的需求。该物质是通过用于生成基因递送系统的先进合成和分析化学方法生产的合成多肽病毒样颗粒的主要成分。对该物质的纯度概况进行了最高计量级别的评估，证明了其可溯源至国际单位制。该物质增加了新兴的定量生物学参考标准工具包。
