Marvasi Massimiliano, Monici Monica, Pantalone Desirée, Cavalieri Duccio
Department of Biology, University of Florence, Florence, Italy.
ASAcampus Joint Laboratory, ASA Res. Div., Deptartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Front Bioeng Biotechnol. 2022 Apr 29;10:873384. doi: 10.3389/fbioe.2022.873384. eCollection 2022.
Wound healing is slowed in Space. Microgravity and possible physical factors associated with Space affect alterations in fibroblast, matrix formation, dysregulation in apoptosis and inflammation. The microbial populations settled on skin, space modules, in space suits, are also playing a pivotal role, as wound healing is also affected by the microbial community. We propose a perspective that includes four domines for the application of human skin microbiota for wound healing in Space: The natural antimicrobial properties of the skin microbiota, the crosstalk of the skin microbiota with the immune system during wound healing, the contribution of the microbiota in precision medicine, and the role of gut-skin and gut-brain axes. A stronger understanding of the connections and metabolic network among bacteria, fungi, the host's immune system and the host metabolism will support the basis for a better wound healing in Space.
太空环境中伤口愈合会减缓。微重力以及与太空相关的可能物理因素会影响成纤维细胞、基质形成、细胞凋亡失调和炎症反应。定居在皮肤、太空舱以及太空服上的微生物群落也起着关键作用，因为伤口愈合也会受到微生物群落的影响。我们提出了一个观点，即在太空中应用人类皮肤微生物群促进伤口愈合包括四个方面：皮肤微生物群的天然抗菌特性、伤口愈合过程中皮肤微生物群与免疫系统的相互作用、微生物群在精准医学中的作用以及肠-皮肤和肠-脑轴的作用。更深入地了解细菌、真菌、宿主免疫系统和宿主代谢之间的联系和代谢网络，将为在太空中实现更好的伤口愈合奠定基础。
