Department of Pediatrics, Division of Pediatric Emergency Medicine, and.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Clin Invest. 2021 May 17;131(10). doi: 10.1172/JCI149327.
Multisystem inflammatory syndrome in children (MIS-C) is a rare but deadly new disease in children that rapidly progresses to hyperinflammation and shock, and can lead to multiple organ failure if unrecognized. It has been found to be temporally associated with the COVID-19 pandemic and is often associated with SARS-CoV-2 exposure in children. In this issue of the JCI, Porritt, Paschold, et al. identify restricted T cell receptor (TCR) β-chain variable domain (Vβ) usage in patients with severe MIS-C, indicating a potential role for SARS-CoV-2 as a superantigen. These findings suggest that a blood test that determines the presence of specific TCRβ variable gene (TRBV) segments may identify patients at risk for severe MIS-C.
儿童多系统炎症综合征（MIS-C）是一种罕见但致命的儿童新疾病，其炎症迅速进展为全身炎症反应和休克，如果不及时识别，可能导致多器官衰竭。现已发现它与 COVID-19 大流行存在时间关联，并且通常与儿童中 SARS-CoV-2 暴露相关。在本期 JCI 中，Porritt、Paschold 等人鉴定出严重 MIS-C 患者的受限 T 细胞受体（TCR）β链可变区（Vβ）使用，表明 SARS-CoV-2 可能作为一种超抗原发挥作用。这些发现表明，一种通过检测特定 TCRβ 可变基因（TRBV）片段是否存在来确定是否存在严重 MIS-C 风险的血液检测可能具有临床应用价值。
