State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong Province, China.
Haematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.
Leukemia. 2022 Jul;36(7):1850-1860. doi: 10.1038/s41375-022-01596-z. Epub 2022 May 16.
Causes of death in persons with haematological cancers include the index cancer, a new cancer or a seemingly unrelated cause such as cardio-vascular disease. These causes are complex and sometimes confounded. We analyzed trends in cause of death in 683,333 persons with an index haematological cancer diagnosed in 1975-2016 reported in the Surveillance, Epidemiology and End Results dataset. Non-cancer deaths were described using standardized mortality ratios. The index cancer was the predominant cause of death amongst persons with plasma cell myeloma, acute lymphoblastic leukaemia and acute myeloid leukaemia. Non-cancer death was the major cause of death in persons with chronic lymphocytic leukaemia, Hodgkin lymphoma and chronic myeloid leukaemia, mostly from cardio-vascular diseases. The greatest relative decrease in index-cancer deaths was amongst persons with Hodgkin lymphoma, chronic myeloid leukaemia and chronic lymphocytic leukaemia, where the proportion of non-cancer deaths increased substantially. Changing distribution of causes of death across haematological cancers reflects substantial progress in some cancers and suggests strategies to improve the survival of persons with haematological cancers in the future.
血液系统癌症患者的死亡原因包括索引癌症、新发癌症或看似无关的原因，如心血管疾病。这些原因很复杂，有时还很复杂。我们分析了 1975 年至 2016 年期间在监测、流行病学和最终结果数据集报告的 683333 名索引血液系统癌症患者的死因趋势。使用标准化死亡率来描述非癌症死亡。在多发性骨髓瘤、急性淋巴细胞白血病和急性髓系白血病患者中，索引癌症是主要的死亡原因。在慢性淋巴细胞白血病、霍奇金淋巴瘤和慢性髓系白血病患者中，非癌症死亡是主要的死亡原因，主要死于心血管疾病。霍奇金淋巴瘤、慢性髓系白血病和慢性淋巴细胞白血病患者的索引癌症死亡率降幅最大，而非癌症死亡率大幅上升。血液系统癌症死因分布的变化反映了某些癌症的显著进展，并为未来改善血液系统癌症患者的生存提供了策略。
