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抗菌漱口水和防腐物质对淋病奈瑟菌的抑制活性。

Inhibitory Activity of Antibacterial Mouthwashes and Antiseptic Substances against Neisseria gonorrhoeae.

机构信息

Department of Microbiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute, Melbourne, Victoria, Australia.

出版信息

Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0004222. doi: 10.1128/aac.00042-22. Epub 2022 May 17.

DOI:10.1128/aac.00042-22
PMID:35579459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9211398/
Abstract

Improved treatment and prevention strategies, such as antimicrobial mouthwashes, may be important for addressing the public health threat of antimicrobial-resistant Neisseria gonorrhoeae. Here, we describe the activity of seven common antibacterial mouthwashes and antiseptics against N. gonorrhoeae isolates, incorporating the use of a human saliva test matrix. Our data demonstrate that antibacterial mouthwashes and antiseptics vary in their ability to inhibit the growth of N. gonorrhoeae and saliva may impact this inhibitory activity.

摘要

改进的治疗和预防策略，如抗菌漱口水，可能对于解决耐抗生素淋病奈瑟菌对公众健康的威胁至关重要。在这里，我们描述了七种常见的抗菌漱口水和防腐剂对淋病奈瑟菌分离株的活性，同时纳入了人类唾液测试基质的使用。我们的数据表明，抗菌漱口水和防腐剂抑制淋病奈瑟菌生长的能力存在差异，而唾液可能会影响这种抑制活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/385f/9211398/e091b414d5e0/aac.00042-22-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/385f/9211398/c7676840c39a/aac.00042-22-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/385f/9211398/e091b414d5e0/aac.00042-22-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/385f/9211398/c7676840c39a/aac.00042-22-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/385f/9211398/e091b414d5e0/aac.00042-22-f002.jpg

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Lancet Infect Dis. 2021 May;21(5):657-667. doi: 10.1016/S1473-3099(20)30778-7. Epub 2021 Mar 4.
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Antiseptic mouthwash for gonorrhoea prevention (OMEGA): a randomised, double-blind, parallel-group, multicentre trial.用于淋病预防的抗菌漱口液（OMEGA）：一项随机、双盲、平行分组、多中心试验。
Lancet Infect Dis. 2021 May;21(5):647-656. doi: 10.1016/S1473-3099(20)30704-0. Epub 2021 Mar 4.
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An open-label, parallel-group, randomised controlled trial of antiseptic mouthwash versus antibiotics for oropharyngeal gonorrhoea treatment (OMEGA2).
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