Wu Nan, Tu Yaqin, Fan Guorun, Ding Jiahui, Luo Jun, Wang Wei, Zhang Chong, Yuan Caiyan, Zhang Handan, Chen Pei, Tan Songwei, Xiao Hongjun
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Asian J Pharm Sci. 2022 Mar;17(2):253-267. doi: 10.1016/j.ajps.2022.01.002. Epub 2022 Feb 25.
The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy (PDT). Hence, in this study, indocyanine green (ICG)-loaded lipid-coated zinc peroxide (ZnO) nanoparticles (ZnO@Lip-ICG) was constructed to realize tumour microenvironment (TME)-responsive self-oxygen supply. Near infrared light irradiation (808 nm), the lipid outer layer of ICG acquires sufficient energy to produce heat, thereby elevating the localised temperature, which results in accelerated ZnO release and apoptosis of tumour cells. The ZnO rapidly generates O in the TME (pH 6.5), which alleviates tumour hypoxia and then enhances the PDT effect of ICG. These results demonstrate that ZnO@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics, and thus, achieve good tumour proliferation suppression.
肿瘤的缺氧特性限制了氧依赖性光动力疗法（PDT）的效率。因此，在本研究中，构建了负载吲哚菁绿（ICG）的脂质包裹过氧化锌（ZnO）纳米颗粒（ZnO@Lip-ICG），以实现肿瘤微环境（TME）响应性的自供氧。近红外光照射（808nm）时，ICG的脂质外层获得足够能量产生热量，从而升高局部温度，导致ZnO加速释放并使肿瘤细胞凋亡。ZnO在TME（pH 6.5）中迅速产生O，减轻肿瘤缺氧，进而增强ICG的PDT效果。这些结果表明，ZnO@Lip-ICG纳米颗粒具有良好的氧自支持特性和出色的PDT/PTT特性，因此实现了良好的肿瘤增殖抑制。
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