School of Nursing, Shandong University of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, 250355, China.
Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Ji'nan, 250355, China.
Chin J Integr Med. 2024 Feb;30(2):171-180. doi: 10.1007/s11655-022-3522-y. Epub 2022 May 18.
The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity, type 2 diabetes mellitus, heart failure, and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory, regulating immunity, lowering blood glucose and lipids, anti-cancer, and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition, they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.
越来越多的证据表明，肠道微生物群在包括肥胖、2 型糖尿病、心力衰竭和非酒精性脂肪肝在内的疾病的病理过程中发挥着重要作用。中药（CM）提取的多糖不仅可以通过抗炎、调节免疫、降低血糖和血脂、抗癌和抗氧化作用来缓解病理状态，还可以促进健康。肠道微生物群落组成和代谢途径的改变是 CM 多糖治疗的潜在机制。此外，它们通过肠道-器官轴发挥作用，或者通过肠道微生物介导的与其他药物或成分的协同作用发挥间接作用。本综述总结了 CM 多糖与肠道微生物群相互作用的分子机制，作为促进健康的潜在益生元。
