Tong Shanshi, Yu Zhilong, Yin Fang, Yang Qilin, Chu Juhang, Huang Luyao, Gao Wenxue, Qian Mingping
Department of General Surgery, Shanghai tenth People's Hospital, Shanghai, China.
State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Front Chem. 2022 Oct 24;10:1026924. doi: 10.3389/fchem.2022.1026924. eCollection 2022.
Pancreatic cancer (PC) is one of the deadliest gastrointestinal malignancies. Advances in molecular biology and surgery have significantly improved survival rates for other tumors in recent decades, but clinical outcomes for PC remained relatively unchanged. Chemodynamic therapy (CDT) and Photothermal therapy (PTT) represent an efficient and relatively safe cancer treatment modality. Here, we synthesized Mn-doped Prussian blue nanoparticles (MnPB NPs) through a simple and mild method, which have a high loading capacity for drugs and excellent CDT/PTT effect. Cell line experiments and animal experiments proved the safety of MnPB NPs. We stimulated the PC cells with MnPB NPs and performed transwell migration assays. The migration of PC cells was reduced company with the decrease of two classical proteins: matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). Moreover, MnPB NPs induced ferroptosis, which mediated the MAPK pathway and achieved tumor elimination in nude mice. This effective and safe strategy controlled by irradiation represents a promising strategy for pancreatic cancer.
胰腺癌（PC）是最致命的胃肠道恶性肿瘤之一。近几十年来，分子生物学和外科手术的进展显著提高了其他肿瘤的生存率，但胰腺癌的临床结果相对没有变化。化学动力疗法（CDT）和光热疗法（PTT）是一种高效且相对安全的癌症治疗方式。在此，我们通过一种简单温和的方法合成了锰掺杂普鲁士蓝纳米颗粒（MnPB NPs），其具有高药物负载能力和出色的CDT/PTT效果。细胞系实验和动物实验证明了MnPB NPs的安全性。我们用MnPB NPs刺激胰腺癌细胞并进行Transwell迁移实验。随着两种经典蛋白——基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-9（MMP-9）的减少，胰腺癌细胞的迁移也随之降低。此外，MnPB NPs诱导铁死亡，其介导丝裂原活化蛋白激酶（MAPK）途径并在裸鼠中实现肿瘤消除。这种由辐射控制的有效且安全的策略是一种有前景的胰腺癌治疗策略。
