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Altered mitochondrial ribosomes in a cold-sensitive mutant of Saccharomyces cerevisiae.

作者信息

Spithill T W, English K J, Nagley P, Linnane A W

出版信息

Mol Biol Rep. 1978 Jun 16;4(2):83-6. doi: 10.1007/BF00775965.

DOI:10.1007/BF00775965
PMID:355861
Abstract

A mutation at a new locus denoted tsr1 which lies very close to the ery1 locus and 21S rRNA gene in mitochondrial DNA of Saccharomyces cerevisiae, confers conditional respiratory deficiency on cells grown at low temperature, namely 18 degrees. Studies on mitochondria isolated from a strain carrying the mutatated tsr1 locus demonstrate that the rate of mitochondrial protein synthesis is cold-senitive at 18 degrees. The large subunit of the mitochondrial ribosomes isolated from the mutant strain is unstable during extraction and the isolated ribosomes are shown to be defective in catalyzing the poly U-directed synthesis of polyphenylalanine. It is concluded that the tsr1 locus is involved in the determination of the properties of the large subunit of the mitochondrial ribosome.

摘要

相似文献

1
Altered mitochondrial ribosomes in a cold-sensitive mutant of Saccharomyces cerevisiae.
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2
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引用本文的文献

1
Biogenesis of mitochondria 51: biochemical characterization of a mitochondrial mutation in Saccharomyces cerevisiae affecting the mitochondrial ribosome by conferring resistance to aminoglycoside antibiotics.线粒体的生物发生51：酿酒酵母中线粒体突变的生化特征，该突变通过赋予对氨基糖苷类抗生素的抗性来影响线粒体核糖体。
Mol Gen Genet. 1979 Jun 7;173(2):159-70. doi: 10.1007/BF00330306.
2
Biogenesis of mitochondria. 53. Physical map of genetic loci in the 21S ribosomal RNA region of mitochondrial DNA in Saccharomyces cerevisiae.线粒体的生物发生。53. 酿酒酵母线粒体DNA 21S核糖体RNA区域遗传位点的物理图谱。
Mol Gen Genet. 1979 Jul 24;174(3):307-16. doi: 10.1007/BF00267804.
3

本文引用的文献

1
The biogenesis of mitochondria. II. The influence of medium composition on the cytology of anaerobically grown Saccharomyces cerevisiae.线粒体的生物发生。II. 培养基成分对厌氧培养的酿酒酵母细胞学的影响。
J Cell Biol. 1968 May;37(2):207-20. doi: 10.1083/jcb.37.2.207.
2
Biogenesis of mitchondria. Phospholipid synthesis in vitro by yeast mitochondrial and microsomal fractions.线粒体的生物发生。酵母线粒体和微粒体部分体外磷脂合成。
Biochem J. 1974 Nov;144(2):265-75. doi: 10.1042/bj1440265.
3
Biogenesis of mitochondria 48: mikamycin resistance in Saccharomyces cerevisiae--a mitochondrial mutation conferring resistance to an antimycin A-like contaminant in mikamycin.
Biogenesis of mitochondria 49 identification and mapping of a new mitochondrial locus (tsr1) which maps within polar region of yeast mitochondrial genome.
Mol Gen Genet. 1978 May 31;161(3):251-9. doi: 10.1007/BF00330998.
线粒体的生物发生48：酿酒酵母中的米卡霉素抗性——一种赋予对米卡霉素中类似抗霉素A污染物抗性的线粒体突变。
Mol Gen Genet. 1977 Mar 7;151(2):127-36. doi: 10.1007/BF00338687.
4
Biogenesis of mitochondria. The effects of membrane unsaturated fatty acid content on the activity and assembly of the yeast mitochondrial protein-synthesizing system.线粒体的生物发生。膜不饱和脂肪酸含量对酵母线粒体蛋白质合成系统活性及组装的影响。
Arch Biochem Biophys. 1975 Aug;169(2):591-600. doi: 10.1016/0003-9861(75)90203-9.