Nachbor Kristine M, Minkus Caroline L
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Am J Ophthalmol Case Rep. 2022 May 5;26:101573. doi: 10.1016/j.ajoc.2022.101573. eCollection 2022 Jun.
To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia.
An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0.5+ in the left eye. Workup was negative for infectious etiologies and chest imaging revealed no pulmonary nodules. She was treated with prednisolone drops and a tapering course of oral prednisone as she started therapy with ruxolitinib for CMML. Inflammation resolved with treatment, and she remained quiet off steroids while on ruxolitinib.
This is the first case report to specifically describe sclerouveitis associated with CMML, despite the known association of this cancer with various inflammatory manifestations. This case demonstrates that CMML may present with scleritis and uveitis, and should be considered as the underlying etiology of inflammatory eye disease in patients with a diagnosis of CMML.
描述一例慢性粒单核细胞白血病患者并发巩膜葡萄膜炎伴渗出性视网膜脱离的病例。
一名82岁患有慢性粒单核细胞白血病（CMML）的女性，出现右眼急性疼痛性发红和视力下降。检查发现右眼有前巩膜炎和后巩膜炎伴渗出性视网膜脱离，右眼房水细胞为2+，左眼为0.5+。感染病因检查结果为阴性，胸部影像学检查未发现肺结节。她开始接受芦可替尼治疗CMML时，使用了泼尼松龙滴眼液和逐渐减量的口服泼尼松疗程。炎症经治疗后消退，在服用芦可替尼期间，她停用类固醇后病情稳定。
这是首例专门描述与CMML相关的巩膜葡萄膜炎的病例报告，尽管已知这种癌症与各种炎症表现有关。该病例表明，CMML可能表现为巩膜炎和葡萄膜炎，对于诊断为CMML的患者，应将其视为炎性眼病的潜在病因。
