Chong Wen K, Khoo Kah Kuen Karen, Mun-Wei Lam, Ismail Abdul-Salim, Yaakub Azhany
Department of Ophthalmology and Visual Sciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.
Department of Ophthalmology, Hospital Pulau Pinang, Georgetown, MYS.
Cureus. 2022 Nov 21;14(11):e31726. doi: 10.7759/cureus.31726. eCollection 2022 Nov.
Simultaneous infections of tuberculosis and toxoplasmosis are uncommon in immunocompetent patients. We report a case of a 30-year-old male who presented with right eye redness and blurring of vision for one month. The visual acuities were hand movement and Snellen 20/30 in the right and left eyes, respectively. Panuveitis and scleritis were found in the right eye, together with dense vitritis and a large choroidal lesion that extended from the inferonasal to the superotemporal quadrants. B-scan ultrasonography of the right eye showed a choroidal detachment with scleral thickening and subtenon fluid. His IgM anti-Toxoplasma antibody was detected, and his QuantiFERON Gold testing was positive. Magnetic resonance imaging (MRI) of the orbit revealed an enhancing intraocular mass at the lateral and inferior aspects of the right globe. The diagnosis of right eye sclerouveitis with presumed tuberculosis and toxoplasmosis co-infections was made. He was treated with a course of oral azithromycin and anti-tubercular therapy along with systemic prednisolone and a topical steroid. The treatment reduced the inflammation; however, the patient suffered from a sequela of chronic uveitis with prolonged hypotony. Medical treatment alone may be insufficient in treating severe infective sclerouveitis, hence surgical intervention might be warranted to provide favorable clinical outcomes.
在免疫功能正常的患者中,结核病和弓形虫病的同时感染并不常见。我们报告一例30岁男性病例,该患者右眼发红、视力模糊1个月。右眼视力为手动,左眼视力为Snellen 20/30。右眼发现全葡萄膜炎和巩膜炎,伴有浓密的玻璃体炎和一个从鼻下象限延伸至颞上象限的大脉络膜病变。右眼B超显示脉络膜脱离,巩膜增厚,Tenon囊下积液。检测到他的IgM抗弓形虫抗体,其全血干扰素γ释放试验呈阳性。眼眶磁共振成像(MRI)显示右眼球外侧和下方有一个强化的眼内肿块。诊断为右眼巩膜葡萄膜炎,推测合并结核病和弓形虫病感染。他接受了一个疗程的口服阿奇霉素和抗结核治疗,同时使用全身泼尼松龙和局部类固醇。治疗减轻了炎症;然而,患者患有慢性葡萄膜炎伴长期低眼压的后遗症。对于严重的感染性巩膜葡萄膜炎,单纯药物治疗可能不足,因此可能需要手术干预以获得良好的临床结果。