Chmiela Tomasz, Węgrzynek Julia, Kasprzyk Amadeusz, Waksmundzki Damian, Wilczek Dawid, Gorzkowska Agnieszka
Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Students' Scientific Association, Department of Neurorehabilitation, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Diabetes Metab Syndr Obes. 2022 May 9;15:1451-1460. doi: 10.2147/DMSO.S359856. eCollection 2022.
Parkinson's disease (PD) is a synucleinopathy, which presents dysautonomia, as its common non-motor symptom. Some research suggests the existing interplay between the autonomic nervous system dysfunction and glucose metabolism dysregulation in PD.
To determine the prevalence of metabolic disorders with particular emphasis on glucose metabolism in patients with PD and atypical parkinsonism (AP).
A retrospective study was performed by analyzing 461 clinical data of consecutive patients diagnosed with PD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) hospitalized from 2019 to 2021 in the authors' institution. The study group included 350 patients (303 PD, 14 MSA, 33 PSP), aged 65.8 ± 9.7 years (42% were female). Laboratory results (fasting glycemia, lipid parameters, TSH, homocysteine and vitamin D3 levels) were collected. The patient's clinical condition was assessed in III part of Unified Parkinson's Disease Rating Scale (UPDRS p. III), Hoehn-Yahr scale, Mini Mental State Examination (MMSE) and Beck Depression Inventory (BDI).
Impaired fasting glycemia (IGF) was more prevalent in PD than in the PSP (43.43% vs 18.18%; p = 0.043). Similarly, PD presented a higher level of fasting glycemia (102.4 ± 16.7 mg/dl vs 92.2 ± 16.1mg/dl; p = 0.042). According to lipid parameters, patients with PD showed lower LDL cholesterol (92.3 ± 44.3mg/dl vs 119 ± 61.0mg/dl; p = 0.016) and lower BMI compared to patients with PSP (26.1 ± 4.0kg/m vs 29.3 ± 4.4 kg/m; p = 0.024), but there were no statistically significant differences in triglycerides (TG) and HDL cholesterol levels. Males with PD presented greater frequency of IFG (35.05% vs 50.6%; p = 0.042), higher fasting glycemia (99.1 ± 14.3mg/dl vs 103.7 ± 14.7mg/dl; p = 0.006), lower total cholesterol, HDL cholesterol, and BMI compared to women with PD.
Our investigation supports an association between synucleinopathies and glucose metabolism dysregulation.
帕金森病（PD）是一种α-突触核蛋白病，自主神经功能障碍是其常见的非运动症状。一些研究表明，PD患者存在自主神经系统功能障碍与葡萄糖代谢失调之间的相互作用。
确定帕金森病（PD）和非典型帕金森综合征（AP）患者中代谢紊乱的患病率，尤其关注葡萄糖代谢情况。
通过分析2019年至2021年在作者所在机构住院的连续诊断为PD、多系统萎缩（MSA）和进行性核上性麻痹（PSP）的461例患者的临床资料进行回顾性研究。研究组包括350例患者（303例PD、14例MSA、33例PSP），年龄65.8±9.7岁（42%为女性）。收集实验室检查结果（空腹血糖、血脂参数、促甲状腺激素、同型半胱氨酸和维生素D3水平）。采用统一帕金森病评定量表（UPDRS第三部分）、霍恩-亚尔分级量表、简易精神状态检查表（MMSE）和贝克抑郁量表（BDI）对患者的临床状况进行评估。
空腹血糖受损（IFG）在PD患者中的患病率高于PSP患者（43.43%对18.18%；p = 0.043）。同样，PD患者的空腹血糖水平更高（102.4±16.7mg/dl对92.2±16.1mg/dl；p = 0.042）。根据血脂参数，与PSP患者相比，PD患者的低密度脂蛋白胆固醇水平较低（92.3±44.3mg/dl对119±61.0mg/dl；p = 0.016），体重指数也较低（26.1±4.0kg/m²对29.3±4.4kg/m²；p = 0.024），但甘油三酯（TG）和高密度脂蛋白胆固醇水平无统计学显著差异。与PD女性患者相比，PD男性患者的IFG发生率更高（35.05%对50.6%；p = 0.042），空腹血糖更高（99.1±14.3mg/dl对103.7±14.7mg/dl；p = 0.006），总胆固醇、高密度脂蛋白胆固醇和体重指数更低。
我们的研究支持α-突触核蛋白病与葡萄糖代谢失调之间存在关联。
