Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Cancer Med. 2022 Dec;11(24):4979-4988. doi: 10.1002/cam4.4830. Epub 2022 May 19.
Pancreatic cancer (PC) remains one of the most lethal human malignancies worldwide. Due to the insidious onset and the rapid progression, most patients with PC are diagnosed at an advanced stage rendering them inoperable. Despite the development of multiple promising chemotherapeutic agents as recommended first-line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance. Recent studies have identified exosomes as essential mediators of intercellular communications during the occurrence of drug resistance. Understanding the underlying molecular mechanisms and complex signaling pathways of exosome-mediated drug resistance will contribute to the improvement of the design of new oncologic therapy regimens. This review focuses on the intrinsic connections between the chemoresistance of PC cells and exosomes in the tumor microenvironment (TME).
胰腺癌（PC）仍然是全球最致命的人类恶性肿瘤之一。由于其隐匿性发病和快速进展，大多数 PC 患者在诊断时已处于晚期，无法进行手术。尽管已经开发了多种有前途的化疗药物作为 PC 的一线治疗推荐药物，但治疗效果在很大程度上受到耐药性的限制。最近的研究表明，外泌体是肿瘤微环境（TME）中细胞间通讯的重要介质。了解外泌体介导的耐药性的潜在分子机制和复杂信号通路将有助于改进新的肿瘤治疗方案的设计。本文重点讨论了 PC 细胞的化疗耐药性与肿瘤微环境中外泌体之间的内在联系。
