Brozek C M, Geha R S
J Clin Invest. 1987 Apr;79(4):1242-8. doi: 10.1172/JCI112943.
The presence of cross-reactive idiotypes on human IgG antibodies of tetanus toxoid (TT) antigen was assessed by examining the capacity of two anti-idiotypic (ID) antisera raised against IgG (Fab')2 anti-TT (idiotype) from two subjects to bind radiolabeled "idiotype" and to inhibit the binding of radiolabeled TT to IgG from unrelated subjects and from family members of the idiotype donors. Idiotypic crossreactivity with unrelated individuals was infrequent and weak but was frequent and stronger among siblings. The strongest idiotypic crossreactivity was seen between identical twins in studies using four anti-ID raised against the anti-TT idiotypes of two sets of twins. The results of the present study suggest that idiotypic determinants restricted to human anti-TT antibodies are, at least in part, encoded by inherited genes, which are infrequently shared among unrelated individuals.
通过检测针对两名受试者的破伤风类毒素（TT）抗原的IgG（Fab'）2抗TT（独特型）产生的两种抗独特型（ID）抗血清结合放射性标记“独特型”的能力，以及抑制放射性标记的TT与无关个体和独特型供体家庭成员的IgG结合的能力，评估破伤风类毒素（TT）抗原的人IgG抗体上交叉反应性独特型的存在情况。与无关个体的独特型交叉反应不常见且较弱，但在兄弟姐妹中较为常见且更强。在使用针对两组双胞胎的抗TT独特型产生的四种抗ID进行的研究中，同卵双胞胎之间的独特型交叉反应最强。本研究结果表明，限于人抗TT抗体的独特型决定簇至少部分由遗传基因编码，这些基因在无关个体中很少共享。
