Department of Dermatology, Andrology & STIs, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.
Andrology. 2022 Sep;10(6):1073-1095. doi: 10.1111/andr.13196. Epub 2022 May 30.
Addiction is a global problem that has many negative consequences on human health as well as the quality of life.
This review aimed to assess the effect of addiction on human male fertility.
A systematic review was conducted on various electronic sites.
The initial literature search identified a total of 5239 articles in all searched databases. After removing duplicates and application of inclusion/exclusion criteria, 177 were potential articles, 112 were omitted because no direct relevance was encountered. Finally, 65 studies were retained for review. They were classified according to the type of addiction into; opioids and cannabinoids (18 articles), alcohol (7 articles), cocaine (2 articles), Androgenic Anabolic steroids (AAS, 15 articles), tobacco (10 articles) and caffeine (13 articles). Most of these recruited articles demonstrated a negative impact of the addressed substance on male fertility with variable levels of evidence.
It was concluded that addiction harms human male fertility that should be put into consideration. More future studies are needed after a proper methodological and statistical approach, including logistic regression analysis, to predict the effect of a specific substance on human male fertility.
成瘾是一个全球性问题，对人类健康和生活质量有许多负面影响。
本综述旨在评估成瘾对男性生育力的影响。
在多个电子网站上进行了系统综述。
最初在所有搜索数据库中总共识别出 5239 篇文献。在去除重复项并应用纳入/排除标准后，有 177 篇潜在文章，由于未遇到直接相关性，其中 112 篇被排除。最后保留了 65 项研究进行综述。根据成瘾类型进行分类，包括阿片类药物和大麻类药物（18 篇）、酒精（7 篇）、可卡因（2 篇）、雄激素合成类固醇（AAS，15 篇）、烟草（10 篇）和咖啡因（13 篇）。这些纳入的文章大多数都表明，所研究的物质对男性生育力有负面影响，但其证据水平各不相同。
成瘾会损害男性生育力，这一点应引起重视。需要进行更多的未来研究，采用适当的方法学和统计学方法，包括逻辑回归分析，以预测特定物质对人类男性生育力的影响。
