Zoologická zahrada Tábor a.s., Dukelských Hrdinů 19, 170 00, Prague 7, Czech Republic.
Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
BMC Vet Res. 2022 May 19;18(1):188. doi: 10.1186/s12917-022-03290-9.
Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity.
SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs.
Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs.
在多个动物物种以及人类中都发现了与长寿相关的基因。本研究的目的是对长寿的意大利卡斯罗犬进行遗传分析，以期找到与长寿相关的基因。
在四个基因 TDRP、MC2R、FBXO25 和 FBXL21 中，具有特定核苷酸的 SNPs 在长寿犬中显著过表达。在 FBXL21 中，与长寿相关的 SNPs 位于外显子中。在 FBXL21 蛋白中，长寿命犬的色氨酸取代了参考犬中的精氨酸。
使用 GWAS 鉴定了与犬长寿相关的四个 SNPs，并通过 DNA 测序进行了验证。我们得出结论，基因 TDRP、MC2R、FBXO25 和 FBXL21 与意大利卡斯罗犬的长寿有关。
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