Wilkinson I M, Anderson J R, Holmes A E
J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):304-12. doi: 10.1136/jnnp.50.3.304.
This paper presents the clinical and pathological data obtained from 42 patients with oligodendroglioma diagnosed over a 20 year period at Addenbrooke's Hospital, Cambridge. In all cases the diagnosis was established unequivocally by histological examination. The principal conclusions of this study were: (1) the outcome was not as favourable as anticipated, nine patients dying within 1 year of diagnosis, and only 10 patients surviving 5 years, (2) age at the time of diagnosis was the single most important prognostic factor, patients under 45 years at diagnosis having a significantly greater survival time than older patients, (3) two other factors had a significantly adverse effect on prognosis, namely the presence of a focal neurological deficit at the time of diagnosis and the presence of nuclear pleomorphism in the tumour when examined histologically, (4) although cells containing glial fibrillary acidic protein were demonstrated in almost every tumour, their number and distribution did not appear to influence the prognosis.
本文呈现了在20年期间于剑桥阿登布鲁克医院确诊的42例少突胶质细胞瘤患者的临床和病理数据。所有病例均通过组织学检查明确诊断。本研究的主要结论如下：（1）结果不如预期的好，9例患者在诊断后1年内死亡，仅10例患者存活5年；（2）诊断时的年龄是唯一最重要的预后因素，诊断时年龄小于45岁的患者比老年患者的存活时间显著更长；（3）另外两个因素对预后有显著不利影响，即诊断时存在局灶性神经功能缺损以及组织学检查时肿瘤中存在核异形性；（4）尽管几乎在每个肿瘤中都发现了含有胶质纤维酸性蛋白的细胞，但其数量和分布似乎并不影响预后。
