Elian M, Dean G
J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):327-32. doi: 10.1136/jnnp.50.3.327.
Multiple sclerosis has been reported to be very uncommon in the West Indies. In previous studies immigrants from the West Indies resident in Greater London had only one-eighth the likelihood of being diagnosed in hospital as having multiple sclerosis compared with those born in the United Kingdom. No studies of the incidence and prevalence of multiple sclerosis were available for London or South East England but there is evidence that it is much the same as occurs in Ireland. In the age groups studied the United Kingdom-born children of West Indian immigrants had an incidence and prevalence of probable multiple sclerosis of the same order as has been reported in Northern Ireland and in the Irish Republic. Although there is evidence that genetic factors play a part, our findings are strong evidence that the cause of the disease is mainly environmental and is therefore potentially preventable.
据报道,多发性硬化症在西印度群岛非常罕见。在之前的研究中,居住在大伦敦地区的西印度群岛移民被医院诊断为患有多发性硬化症的可能性只有在英国出生者的八分之一。目前尚无关于伦敦或英格兰东南部多发性硬化症发病率和患病率的研究,但有证据表明,其情况与爱尔兰大致相同。在所研究的年龄组中,西印度群岛移民在英国出生的子女中,可能患多发性硬化症的发病率和患病率与北爱尔兰和爱尔兰共和国所报告的情况相当。虽然有证据表明遗传因素起了一定作用,但我们的研究结果有力地证明,该病的病因主要是环境因素,因此有可能预防。