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研究羔羊驼背的研究人员中的多发性硬化症:最新报告。

Multiple sclerosis in research workers studying swayback in lambs: an updated report.

作者信息

Dean G, McDougall E I, Elian M

出版信息

J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):859-65. doi: 10.1136/jnnp.48.9.859.

DOI:10.1136/jnnp.48.9.859
PMID:4045479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1028484/
Abstract

Four out of seven research workers into swayback disease, a neurological disease of lambs, developed symptoms and signs of multiple sclerosis, and were reported in 1947. A further worker later joined the group. All of the original seven have died and two at necropsy had multiple areas of demyelination in the brain and spinal cord. The chance of four or more out of a random group of eight men developing multiple sclerosis is about one in a thousand million. Multiple sclerosis has not occurred in other workers on swayback disease elsewhere.

摘要

在研究羔羊神经疾病——摇摆病的七名研究人员中,有四人出现了多发性硬化症的症状和体征,并于1947年被报道。后来又有一名研究人员加入了这个团队。最初的七人都已去世,其中两人尸检时发现大脑和脊髓有多处脱髓鞘病变。在随机挑选的八名男性中,有四人或更多人患多发性硬化症的概率约为十亿分之一。在其他地方研究摇摆病的工作人员中并未出现多发性硬化症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/2c4bf23b2703/jnnpsyc00113-0011-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/8447a994966f/jnnpsyc00113-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/5b6d11ba3d1b/jnnpsyc00113-0011-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/24f7d0b157b8/jnnpsyc00113-0011-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/2c4bf23b2703/jnnpsyc00113-0011-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/8447a994966f/jnnpsyc00113-0011-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/5b6d11ba3d1b/jnnpsyc00113-0011-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/24f7d0b157b8/jnnpsyc00113-0011-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d8c/1028484/2c4bf23b2703/jnnpsyc00113-0011-d.jpg

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1
Multiple sclerosis in research workers studying swayback in lambs: an updated report.研究羔羊驼背的研究人员中的多发性硬化症:最新报告。
J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):859-65. doi: 10.1136/jnnp.48.9.859.
2
Further observations on swayback. II. Histochemical localisation of cytochrome oxidase activity in the central nervous system.关于 swayback 的进一步观察。II. 细胞色素氧化酶活性在中枢神经系统中的组织化学定位。
J Comp Pathol. 1963 Jan;73:61-7.
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MEASUREMENT OF NERVE CELL DAMAGE IN THE SPINAL CORD OF LAMBS AFFECTED WITH SWAYBACK.患有摇摆病的羔羊脊髓中神经细胞损伤的测量
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COPPER DEFICIENCY IN RELATION TO SWAYBACK IN SHEEP. II. EFFECT OF DOSING YOUNG LAMBS WITH MOLYBDATE AND SULPHATE.与绵羊摇背症相关的铜缺乏。II. 给幼龄羔羊投喂钼酸盐和硫酸盐的效果
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Multiple sclerosis and the swayback story.多发性硬化症与脊柱前凸的故事。
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The association between swayback and disseminated sclerosis.脊柱前凸与播散性硬化之间的关联。
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Swayback (enzootic ataxia) in Alberta lambs.艾伯塔省羔羊的 swayback(地方性共济失调)
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本文引用的文献

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Copper concentration and cytochrome-oxidase and ribonuclease activities in the brains of copper-deficient lambs.缺铜羔羊大脑中的铜浓度、细胞色素氧化酶和核糖核酸酶活性
Biochem J. 1962 Dec;85(3):629-32. doi: 10.1042/bj0850629.
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Disseminated sclerosis in man and experimentation with sheep.人类的播散性硬化症与绵羊实验
Glasgow Med J. 1951 Oct;32(10):302-10.
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Demyelination in lambs born of ewes maintained on high intakes of sulphate and molybdate.母羊摄入大量硫酸盐和钼酸盐后所产羔羊的脱髓鞘病变
Sci Prog. 2013;96(Pt 3):213-23. doi: 10.3184/003685013X13712193905878.
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Non-malignant disease mortality in meat workers: a model for studying the role of zoonotic transmissible agents in non-malignant chronic diseases in humans.肉类工作者的非恶性疾病死亡率:研究人畜共患传染性病原体在人类非恶性慢性疾病中作用的模型。
Occup Environ Med. 2007 Dec;64(12):849-55. doi: 10.1136/oem.2006.030825. Epub 2007 Jun 29.
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Infection and the etiology and pathogenesis of multiple sclerosis.感染与多发性硬化症的病因及发病机制
Curr Neurol Neurosci Rep. 2001 May;1(3):271-6. doi: 10.1007/s11910-001-0030-x.
6
Responding to reported clusters of common diseases: the case of multiple sclerosis.应对报告的常见疾病聚集现象:以多发性硬化症为例。
Can J Public Health. 1997 Jul-Aug;88(4):277-9. doi: 10.1007/BF03404797.
7
Multiple sclerosis among the United Kingdom-born children of immigrants from the West Indies.西印度群岛移民在英国出生的子女中的多发性硬化症。
J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):327-32. doi: 10.1136/jnnp.50.3.327.
8
Do nurses or doctors have an increased risk of developing multiple sclerosis?护士或医生患多发性硬化症的风险会增加吗?
J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):899-902. doi: 10.1136/jnnp.53.10.899.
Nature. 1960 Jan 2;185:20-2. doi: 10.1038/185020a0.
4
CYTOCHROME OXIDASE DEFICIENCY IN THE MOTOR NEURONES OF COPPER-DEFICIENT LAMBS: A HISTOCHEMICAL STUDY.缺铜羔羊运动神经元中的细胞色素氧化酶缺乏症:一项组织化学研究。
Res Vet Sci. 1965 Apr;6:170-7.
5
VETERINARY WORKERS AND DISSEMINATED SCLEROSIS.兽医工作者与多发性硬化症
J Neurol Neurosurg Psychiatry. 1963 Dec;26(6):514-5. doi: 10.1136/jnnp.26.6.514.
6
Copper deficiency in relation to swayback in sheep. I. Effect of molybdate and sulphate supplements during pregnancy.绵羊铜缺乏与摇背病的关系。I. 孕期补充钼酸盐和硫酸盐的影响
J Comp Pathol. 1963 Apr;73:208-13. doi: 10.1016/s0368-1742(63)80024-7.
7
Further observations on swayback. I. Transitional pathology.关于鞍背的进一步观察。I. 过渡性病理学。
J Comp Pathol. 1963 Jan;73:51-60. doi: 10.1016/s0368-1742(63)80006-5.
8
Swayback in south-east Scotland. I. Field aspects.苏格兰东南部的脊柱前凸。I. 实地情况。
J Comp Pathol. 1960 Oct;70:396-410. doi: 10.1016/s0368-1742(60)80038-0.
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Encephalitogenic peptides from spinal cord.来自脊髓的致脑炎肽
Nature. 1966 Mar 26;209(5030):1354-5. doi: 10.1038/2091354a0.
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Structural changes of the central nervous system in swayback (enzootic ataxia) of lambs. IV. Electron microscopy of the white matter of the spinal cord.羔羊晃背病(地方性共济失调)中枢神经系统的结构变化。IV. 脊髓白质的电子显微镜观察
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