State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials, Nanjing Tech University, Nanjing, 210009, P. R. China.
Department of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, China.
Adv Sci (Weinh). 2022 Aug;9(22):e2201254. doi: 10.1002/advs.202201254. Epub 2022 May 21.
The pH value in the wound milieu plays a key role in cellular processes and cell cycle processes involved in the process of wound healing. Here, a microfluidic assembly technique is employed to fabricate micro-gel ensembles that can precisely tune the pH value of wound surface and accelerate wound healing. The micro-gel ensembles consist of poly (hydroxypropyl acrylate-co-acrylic acid)-magnesium ions (poly-(HPA-co-AA)-Mg ) gel and carboxymethyl chitosan (CMCS) gel, which can release and absorb hydrogen ion (H ) separately at different stages of healing in response to the evolution of wound microenvironment. By regulating the wound pH to affect the proliferation and migration of cell on the wound and the activity of various biological factors in the wound, the physiological processes are greatly facilitated which results in much accelerated healing of chronic wound. This work presents an effective strategy in designing wound healing materials with vast potentials for chronic wound management.
在创伤微环境中，pH 值在参与创伤愈合的细胞过程和细胞周期过程中起着关键作用。在这里，采用微流体制备技术来制备微凝胶聚集体，可精确调节创面 pH 值并加速创面愈合。微凝胶聚集体由聚（羟丙基丙烯酰胺-co-丙烯酸）-镁离子（poly-(HPA-co-AA)-Mg ）凝胶和羧甲基壳聚糖（CMCS）凝胶组成，可在愈合的不同阶段分别释放和吸收氢离子（H ），以响应创面微环境的演变。通过调节创面 pH 值来影响创面细胞的增殖和迁移以及创面中各种生物因素的活性，极大地促进了生理过程，从而大大加速了慢性创面的愈合。这项工作为设计具有慢性创面管理广阔潜力的创面愈合材料提供了一种有效的策略。
