Sanchez-Conde Francisco G, Jimenez-Vazquez Eric N, Auerbach David S, Jones David K
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, United States.
Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY, United States.
Front Mol Neurosci. 2022 May 3;15:890368. doi: 10.3389/fnmol.2022.890368. eCollection 2022.
The ERG1 potassium channel, encoded by , has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.
由[基因名称未给出]编码的ERG1钾通道长期以来一直与心脏电兴奋性相关。然而，越来越多的研究表明，ERG1在整个人体生理过程中发挥作用，包括大脑。ERG1是神经元兴奋性的调节因子，ERG1变体与神经元疾病（如癫痫和精神分裂症）有关，并且ERG1是神经元病理生理学的潜在治疗靶点。本综述总结了关于ERG1通道结构与功能、ERG1与哺乳动物大脑关系的当前研究现状，并突出了尚未解答的关键问题。
