Shen Jia-Cheng, Qi Qin, Han Dong, Liu Shi-Min, Huang Rong, Zhu Yi, Zheng Han-Dan, Gu Kan, Wu Huan-Gan, Liu Hui-Rong
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.
Evid Based Complement Alternat Med. 2022 May 13;2022:5814048. doi: 10.1155/2022/5814048. eCollection 2022.
Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Bile acids (BAs) can be used as effector molecules to regulate physiological processes in the gut, and NRs are important receptors for bile acid signaling. Relevant studies have shown that NRs are closely related to the occurrence of Crohn's disease (CD). Although the mechanism of NRs in CD has not been clarified completely, growing evidence shows that NRs play an important role in regulating intestinal immunity, mucosal barrier, and intestinal flora. NRs can participate in the progress of CD by mediating inflammation, immunity, and autophagy. As the important parts of traditional Chinese medicine (TCM) therapy, acupuncture and moxibustion in the treatment of CD curative mechanism can get a lot of research support. At the same time, acupuncture and moxibustion can regulate the changes of related NRs. Therefore, to explore whether acupuncture can regulate BA circulation and NRs expression and then participate in the disease progression of CD, a new theoretical basis for acupuncture treatment of CD is provided.
核受体（NRs）是依赖配体的转录因子，可调节靶基因的转录。胆汁酸（BAs）可作为效应分子调节肠道生理过程，而核受体是胆汁酸信号传导的重要受体。相关研究表明，核受体与克罗恩病（CD）的发生密切相关。虽然核受体在克罗恩病中的机制尚未完全阐明，但越来越多的证据表明，核受体在调节肠道免疫、黏膜屏障和肠道菌群方面发挥着重要作用。核受体可通过介导炎症、免疫和自噬参与克罗恩病的进展。作为中医治疗的重要组成部分，针灸治疗克罗恩病的疗效机制可获得大量研究支持。同时，针灸可调节相关核受体的变化。因此，为探索针刺是否能调节胆汁酸循环和核受体表达进而参与克罗恩病的疾病进展，为针刺治疗克罗恩病提供新的理论依据。
