Van der Cruijsen Joris, Jonker Zeb D, Andrinopoulou Eleni-Rosalina, Wijngaarden Jessica E, Tangkau Ditte A, Tulen Joke H M, Frens Maarten A, Ribbers Gerard M, Selles Ruud W
Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Department of Biomechanical Engineering, Delft University of Technology, Delft, Netherlands.
Front Hum Neurosci. 2022 May 4;16:842954. doi: 10.3389/fnhum.2022.842954. eCollection 2022.
Transcranial direct current stimulation (tDCS) over the contralateral primary motor cortex of the target muscle (conventional tDCS) has been described to enhance corticospinal excitability, as measured with transcranial magnetic stimulation. Recently, tDCS targeting the brain regions functionally connected to the contralateral primary motor cortex (motor network tDCS) was reported to enhance corticospinal excitability more than conventional tDCS. We compared the effects of motor network tDCS, 2 mA conventional tDCS, and sham tDCS on corticospinal excitability in 21 healthy participants in a randomized, single-blind within-subject study design. We applied tDCS for 12 min and measured corticospinal excitability with TMS before tDCS and at 0, 15, 30, 45, and 60 min after tDCS. Statistical analysis showed that neither motor network tDCS nor conventional tDCS significantly increased corticospinal excitability relative to sham stimulation. Furthermore, the results did not provide evidence for superiority of motor network tDCS over conventional tDCS. Motor network tDCS seems equally susceptible to the sources of intersubject and intrasubject variability previously observed in response to conventional tDCS.
经颅直流电刺激（tDCS）作用于目标肌肉对侧的初级运动皮层（传统tDCS），已被描述为可增强皮质脊髓兴奋性，这是通过经颅磁刺激测量得出的。最近，有报道称，靶向与对侧初级运动皮层功能相连的脑区的tDCS（运动网络tDCS）比传统tDCS更能增强皮质脊髓兴奋性。在一项随机、单盲的受试者内研究设计中，我们比较了运动网络tDCS、2 mA传统tDCS和假tDCS对21名健康参与者皮质脊髓兴奋性的影响。我们施加tDCS 12分钟，并在tDCS前以及tDCS后0、15、30、45和60分钟用经颅磁刺激（TMS）测量皮质脊髓兴奋性。统计分析表明，相对于假刺激，运动网络tDCS和传统tDCS均未显著增加皮质脊髓兴奋性。此外，结果并未提供运动网络tDCS优于传统tDCS的证据。运动网络tDCS似乎同样容易受到先前在对传统tDCS反应中观察到的受试者间和受试者内变异性来源的影响。
