Kumar Lekshmi R G, Paul Preethy Treesa, Anas K K, Tejpal C S, Chatterjee N S, Anupama T K, Mathew Suseela, Ravishankar C N
ICAR-Central Institute of Fisheries Technology (CIFT), Cochin-29, Cochin, India.
ICAR-Central Institute of Fisheries Technology (CIFT), Veraval Research Centre, Veraval, India.
J Appl Phycol. 2022;34(4):2173-2185. doi: 10.1007/s10811-022-02749-4. Epub 2022 May 17.
Phlorotannins, a seaweed based class of polyphenolic compounds, have proven to possess potential bioactivities such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancerous, neuroprotection etc. These bioactivities have further increased demand globally and sustainable techniques such as supercritical fluid extraction, microwave assisted extraction, enzyme assisted extraction, extraction using deep eutectic solvents etc. are being explored currently for production of phlorotannin-rich extracts. In spite of such well documented bioactivities, very few phlorotannin-based nutraceuticals are available commercially which highlights the significance of generating consumer awareness about their physiological benefits. However, for industry level commercialization accurate quantification of phlorotannins with respect to the different classes is vital requiring sophisticated analytical techniques such as mass spectrometry, H-NMR spectroscopy etc. owing to the wide structural diversity. This review summarizes the extraction and bioactivities of phlorotannins based on the findings of in vivo and in vitro studies.
褐藻多酚是一类基于海藻的多酚化合物，已被证明具有潜在的生物活性，如抗氧化、抗菌、抗过敏、抗糖尿病、抗炎、抗癌、神经保护等。这些生物活性进一步提高了全球对其的需求，目前正在探索超临界流体萃取、微波辅助萃取、酶辅助萃取、使用深共熔溶剂萃取等可持续技术来生产富含褐藻多酚的提取物。尽管褐藻多酚具有如此充分记录的生物活性，但市面上很少有基于褐藻多酚的营养保健品，这凸显了提高消费者对其生理益处认识的重要性。然而，对于工业规模的商业化而言，由于褐藻多酚结构差异很大，准确量化不同类别的褐藻多酚至关重要，这需要质谱、H-NMR光谱等复杂的分析技术。本综述基于体内和体外研究结果，总结了褐藻多酚的提取和生物活性。
