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遗传性牙龈纤维瘤病与发育异常:一例报告

Hereditary Gingival Fibromatosis and Developmental Anomalies: A Case Report.

作者信息

Afonso Rhaina A, Godinho Géssica V, Silva Cristhiane A, Silva Everton J, Volpato Luiz E

机构信息

Department of Dentistry, Hospital de Câncer de Mato Grosso, Cuiabá, BRA.

Department of Environment and Health, Universidade de Cuiabá, Cuiabá, BRA.

出版信息

Cureus. 2022 Apr 17;14(4):e24219. doi: 10.7759/cureus.24219. eCollection 2022 Apr.

DOI:10.7759/cureus.24219
PMID:35602830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9117822/
Abstract

Hereditary gingival fibromatosis is the most common genetic form of gingival fibromatosis that develops as a slow, progressive, benign, localized, or generalized enlargement of the keratinized gingiva. It is a genetically heterogeneous disorder transmitted as an autosomal dominant or autosomal recessive trait or appears sporadically. Here, we report a case of a male patient with generalized gingival hyperplasia with great tissue extension to the palatal region, bilateral mandibular torus, bilateral exostosis in the maxillary posterior region, anterior open bite, and diastema in anterior maxilla and mandible teeth. The mucous membranes were healthy and normal colored, with pale pink gums and firm teeth upon palpation. Computed tomography also revealed images suggestive of supernumerary teeth. The patient reported that his mother and a maternal aunt have the same gingival condition. Considering the gingival characteristic, the patient's family history, and the absence of other possible etiological factors of gingival hyperplasia, the diagnostic hypothesis was hereditary gingival fibromatosis. The surgical removal of the enlarged tissue through gingivectomy with internal bevel, osteoplasty, and removal of supernumerary teeth with a subsequent filling of the surgical sites with platelet and leukocyte-rich fibrin membranes in the same surgical time presented good functional and aesthetic results for the young patient with hereditary gingival fibromatosis. It is a viable possibility for clinical management of similar cases.

摘要

遗传性牙龈纤维瘤病是牙龈纤维瘤病最常见的遗传形式,表现为角化牙龈缓慢、进行性、良性、局限性或全身性肿大。它是一种遗传异质性疾病,以常染色体显性或隐性性状遗传,或散发出现。在此,我们报告一例男性患者,患有广泛性牙龈增生,病变组织广泛延伸至腭部区域、双侧下颌隆突、上颌后部区域双侧外生骨疣、前牙开颌以及上颌和下颌前牙区牙间隙。黏膜健康且颜色正常,牙龈呈淡粉色,触诊时牙齿牢固。计算机断层扫描还显示有额外牙的影像。患者报告其母亲和一位姨妈有相同的牙龈状况。考虑到牙龈特征、患者家族史以及不存在其他可能导致牙龈增生的病因,诊断假设为遗传性牙龈纤维瘤病。在同一手术时间通过内斜切口牙龈切除术、骨成形术切除增生组织以及拔除额外牙,随后用富含血小板和白细胞的纤维蛋白膜填充手术部位,对于患有遗传性牙龈纤维瘤病的年轻患者而言,取得了良好的功能和美学效果。这是类似病例临床管理的一种可行方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/a05d88c329c1/cureus-0014-00000024219-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/849accd1dcd5/cureus-0014-00000024219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/afd1f006bbf3/cureus-0014-00000024219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/b47565dd0f11/cureus-0014-00000024219-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/a05d88c329c1/cureus-0014-00000024219-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/849accd1dcd5/cureus-0014-00000024219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/afd1f006bbf3/cureus-0014-00000024219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/b47565dd0f11/cureus-0014-00000024219-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d925/9117822/a05d88c329c1/cureus-0014-00000024219-i04.jpg

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Autologous platelet concentrates in maxillofacial regenerative therapy.自体血小板浓缩物在颌面再生治疗中的应用。
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Hereditary Gingival Fibromatosis: a Case Report with Seven-Year Follow-up.遗传性牙龈纤维瘤病:一例随访七年的病例报告
Acta Stomatol Croat. 2018 Sep;52(3):254-258. doi: 10.15644/asc52/3/9.
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REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis.REST基因最后外显子截短突变导致遗传性牙龈纤维瘤病。
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Hereditary gingival fibromatosis: Characteristics and treatment approach.遗传性牙龈纤维瘤病:特征与治疗方法
J Clin Exp Dent. 2017 Apr 1;9(4):e599-e602. doi: 10.4317/jced.53644. eCollection 2017 Apr.
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