三磷酸腺苷（ATP）诱导的来自大肠杆菌K-12的限制性内切核酸酶的构象变化。
ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12.
作者信息
Bickle T A, Brack C, Yuan R
出版信息
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3099-103. doi: 10.1073/pnas.75.7.3099.
Abstract
ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.
摘要
三磷酸腺苷（ATP）可诱导大肠杆菌K-12限制酶发生构象变化，使其能够区分未修饰和修饰的DNA识别序列。这种构象变化不需要ATP水解。然而，DNA切割需要ATP水解。
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