Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
PLoS One. 2022 May 23;17(5):e0268903. doi: 10.1371/journal.pone.0268903. eCollection 2022.
Neospora caninum (N. caninum) is known to be a major cause of reproductive failure in cattle herds around the world. Therefore, the current comprehensive study was performed to estimate the global prevalence of N. caninum infection in bovines that had an abortion and aborted fetuses.
In this study, PubMed, ScienceDirect, Web of Science, Scopus, and ProQuest databases were systematically searched for relevant studies up until November 4, 2021. Pooled prevalence and corresponding 95% confidence intervals (CI) were estimated using a random effect model. Other analyzes performed on the data of this study include sensitivity analysis, publication bias test, and quality assessment.
The final analyses included 71 studies conducted on 2965 abortive cattle and 4805 aborted fetuses. The overall prevalence rates of N. caninum infection in bovines that had an abortion were 47% and 1% using serological and molecular methods. Furthermore, overall prevalence rates of N. caninum infection in bovine aborted fetuses globally were 35% (95% CI: 8%-62%) and 43% (95% CI: 35%-52%) using serological and molecular methods.
The results of this study showed the high prevalence of N. caninum infection in bovines that had an abortion and aborted fetuses. It is hoped that the results of this study will help prevent abortion in bovines around the world and encourage further studies to determine the impact of this parasite on the occurrence of abortion that may help reduce the economic damage caused by abortion worldwide.
刚地弓形虫（N. caninum）已知是导致全球牛群繁殖失败的主要原因。因此，目前进行了一项综合研究，以估计患有流产和流产胎儿的牛中刚地弓形虫感染的全球患病率。
本研究系统检索了 PubMed、ScienceDirect、Web of Science、Scopus 和 ProQuest 数据库，以获取截至 2021 年 11 月 4 日的相关研究。使用随机效应模型估计合并患病率和相应的 95%置信区间（CI）。对本研究数据进行的其他分析包括敏感性分析、发表偏倚检验和质量评估。
最终分析包括对 2965 头流产牛和 4805 头流产胎儿进行的 71 项研究。使用血清学和分子方法，牛流产时刚地弓形虫感染的总体患病率分别为 47%和 1%。此外，全球使用血清学和分子方法的牛流产胎儿中刚地弓形虫感染的总体患病率分别为 35%（95%CI：8%-62%）和 43%（95%CI：35%-52%）。
本研究结果表明，流产牛和流产胎儿中刚地弓形虫感染的患病率较高。希望本研究的结果将有助于预防全球牛的流产，并鼓励进一步研究确定该寄生虫对流产发生的影响，这可能有助于减少全球因流产造成的经济损失。
