Functional Imaging Laboratory, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.
Georg-August University of Göttingen, Göttingen, Germany.
Elife. 2022 May 24;11:e74813. doi: 10.7554/eLife.74813.
During deep anesthesia, the electroencephalographic (EEG) signal of the brain alternates between bursts of activity and periods of relative silence (suppressions). The origin of burst-suppression and its distribution across the brain remain matters of debate. In this work, we used functional magnetic resonance imaging (fMRI) to map the brain areas involved in anesthesia-induced burst-suppression across four mammalian species: humans, long-tailed macaques, common marmosets, and rats. At first, we determined the fMRI signatures of burst-suppression in human EEG-fMRI data. Applying this method to animal fMRI datasets, we found distinct burst-suppression signatures in all species. The burst-suppression maps revealed a marked inter-species difference: in rats, the entire neocortex engaged in burst-suppression, while in primates most sensory areas were excluded-predominantly the primary visual cortex. We anticipate that the identified species-specific fMRI signatures and whole-brain maps will guide future targeted studies investigating the cellular and molecular mechanisms of burst-suppression in unconscious states.
在深度麻醉期间，大脑的脑电图 (EEG) 信号在活动爆发和相对安静期（抑制期）之间交替。爆发抑制的起源及其在大脑中的分布仍然存在争议。在这项工作中，我们使用功能磁共振成像 (fMRI) 来绘制四个哺乳动物物种（人类、长尾猕猴、普通狨猴和大鼠）中麻醉诱导的爆发抑制所涉及的脑区图谱。首先，我们确定了人类 EEG-fMRI 数据中爆发抑制的 fMRI 特征。将该方法应用于动物 fMRI 数据集，我们在所有物种中都发现了独特的爆发抑制特征。爆发抑制图谱揭示了明显的种间差异：在大鼠中，整个新皮质都参与了爆发抑制，而在灵长类动物中，大多数感觉区域被排除在外——主要是初级视觉皮层。我们预计，所确定的物种特异性 fMRI 特征和全脑图谱将指导未来针对无意识状态下爆发抑制的细胞和分子机制的靶向研究。
