Few J D, Unwin R J, Carmichael D J, James V H
J Steroid Biochem. 1987 Feb;26(2):265-71. doi: 10.1016/0022-4731(87)90081-1.
We have measured saliva aldosterone concentration (SA) at frequent intervals in subjects going about their normal daytime activities. Four hourly sampling sufficed to give a reasonable estimate of mean diurnal SA but hourly sampling is necessary if it is desired to study the temporal pattern of SA. In subjects with normal or elevated mean levels, SA fluctuated considerably suggestive of several distinct episodes of aldosterone secretion. Such fluctuations show little correlation with the concentrations in saliva of glucocorticoids (cortisol + cortisone) nor are they consistent with a circadian rhythm of aldosterone secretion. We suggest that they may represent responses to such stimuli as eating, drinking or physical activity, and possibly to other as yet unidentified factors. These observations show the importance of comprehensive diurnal assessment of aldosterone level in physiological and pathological investigations. Because of its non-invasive nature and the high productivity of the assay, measurement of SA is ideally suited for this purpose.
我们在进行日常白天活动的受试者中频繁测量唾液醛固酮浓度（SA）。每四小时采样一次足以合理估计SA的平均昼夜水平，但如果想要研究SA的时间模式，则需要每小时采样。在平均水平正常或升高的受试者中，SA波动很大，提示醛固酮分泌有几个不同的阶段。这种波动与唾液中糖皮质激素（皮质醇+可的松）的浓度几乎没有相关性，也不符合醛固酮分泌的昼夜节律。我们认为，它们可能代表对饮食、饮水或身体活动等刺激的反应，也可能对其他尚未确定的因素产生反应。这些观察结果表明，在生理和病理研究中全面昼夜评估醛固酮水平非常重要。由于其非侵入性性质和检测的高产出率，SA测量非常适合此目的。
