Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.
Clin Interv Aging. 2022 May 18;17:811-824. doi: 10.2147/CIA.S361876. eCollection 2022.
To investigate the cross-sectional associations of self-reported sleep characteristics with cardiovascular diseases (CVDs) and cardiovascular multimorbidity in older adults living in rural Eastern China.
This population-based study included 4618 participants (age ≥65 years; 56.5% women) living in rural Eastern China. In March-September 2018, data were collected through interviews, clinical examinations, neuropsychological testing, and laboratory tests. Sleep parameters were assessed using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Score, and Berlin questionnaire. Coronary heart disease (CHD), heart failure (HF), and stroke were defined according to in-person interviews, clinical and neurological examinations, and electrocardiogram examination. Data were analyzed using logistic regression and restricted cubic spline regression.
CHD was diagnosed in 991 participants, HF in 135 participants, and stroke in 696 participants. The multivariable-adjusted odds ratio (OR) of CHD was 1.27 (95% CI, 1.09-1.49) for sleep duration ≤6 hours/night (vs >6-8 hours/night), 1.40 (1.20-1.62) for poor sleep quality, and 1.22 (1.04-1.43) for high risk for obstructive sleep apnea (OSA). The OR of HF was 2.16 (1.38-3.39) for sleep duration >8 hours/night, and 1.76 (1.22-2.54) for high risk for OSA. In addition, the OR of stroke was 1.23 (1.04-1.46) for poor sleep quality, 1.32 (1.01-1.72) for excessive daytime sleepiness, and 1.42 (1.19-1.70) for high risk for OSA. The associations of poor sleep with cardiovascular multimorbidity (≥2 CVDs) were stronger than that of sleep problems with a single CVD.
Extreme sleep duration, high risk for OSA, and other sleep problems were associated with CVDs, especially cardiovascular multimorbidity.
调查中国东部农村老年人自我报告的睡眠特征与心血管疾病（CVD）及心血管多种疾病的横断面关联。
本基于人群的研究纳入了 4618 名参与者（年龄≥65 岁；56.5%为女性），他们居住在中国东部农村。2018 年 3 月至 9 月期间，通过访谈、临床检查、神经心理学测试和实验室测试收集数据。使用匹兹堡睡眠质量指数、爱泼沃斯嗜睡量表和柏林问卷评估睡眠参数。根据面对面访谈、临床和神经检查以及心电图检查定义冠心病（CHD）、心力衰竭（HF）和中风。使用逻辑回归和限制立方样条回归进行数据分析。
991 名参与者被诊断为 CHD，135 名参与者被诊断为 HF，696 名参与者被诊断为中风。多变量调整后的比值比（OR）显示，与每晚睡眠时间>6-8 小时相比，睡眠时间≤6 小时/夜（OR，1.27；95%CI，1.09-1.49）、睡眠质量差（OR，1.40；1.20-1.62）和阻塞性睡眠呼吸暂停（OSA）高危（OR，1.22；1.04-1.43）与 CHD 的发生风险增加相关。与每晚睡眠时间>8 小时/夜相比，HF 的 OR 为 2.16（1.38-3.39），OSA 高危的 OR 为 1.76（1.22-2.54）。此外，与睡眠质量差（OR，1.23；1.04-1.46）、日间过度嗜睡（OR，1.32；1.01-1.72）和 OSA 高危（OR，1.42；1.19-1.70）相关的风险增加。与睡眠问题单一 CVD 相比，睡眠质量差与心血管多种疾病（≥2 种 CVD）的关联更强。
极端的睡眠时间、OSA 高风险和其他睡眠问题与 CVD 相关，尤其是心血管多种疾病。
