Canakkale Onsekiz Mart University Engineering Faculty Food Engineering, Canakkale, Turkey.
Lett Appl Microbiol. 2022 Sep;75(3):598-606. doi: 10.1111/lam.13747. Epub 2022 Jun 5.
The detection of resistant strains of Clostridioides difficile against existing antibiotics and the side effects led to the investigation of alternative agents. Inhibition zones of various essential oils to four strains of C.difficile and other Clostridium species ranged from 8·32 to 44·18 mm. The highest zone was observed in cinnamon and tea tree essential oils. and The MIC values varied between 0·39-25 (%, v/v). The main components were cinnamaldehyde (85·64%) in cinnamon essential oil, 4-terpineol (83·6%) was determined in tea tree essential oil. Additive effects were found between cinnamon essential oil and vancomycin and between cinnamon and tea tree essential oils, and the FICI values were 0·512 and 0·517, respectively. Both cinnamon and tea tree essential oils showed antibiofilm activities against all tested C. difficile strains at all tested concentrations. Essential oils may be used as a supplement in addition to treatment in the control of C. difficile-related diseases.
检测现有抗生素对难辨梭状芽孢杆菌耐药株的作用及副作用，导致了替代药物的研究。不同精油对 4 株艰难梭菌和其他梭菌的抑菌圈直径范围为 8·32-44·18mm。肉桂和茶树精油的抑菌圈最大，MIC 值在 0·39-25（%，v/v）之间变化。肉桂精油的主要成分是肉桂醛（85·64%），茶树精油的主要成分是 4-萜品醇（83·6%）。肉桂精油与万古霉素之间以及肉桂和茶树精油之间存在协同作用，FICI 值分别为 0·512 和 0·517。肉桂和茶树精油在所有测试浓度下均对所有测试的艰难梭菌菌株表现出抗生物膜活性。精油可作为治疗艰难梭菌相关疾病的辅助手段。
