Culebras Mario, Barrett Anthony, Pishnamazi Mahboubeh, Walker Gavin Michael, Collins Maurice N
Stokes Laboratories, School of Engineering, Bernal Institute, University of Limerick, Plassy Technological Park, Limerick V94 T9PX, Ireland.
Department of Chemical Sciences, Bernal Institute, Synthesis and Solid State Pharmaceutical Centre (SSPC), University of Limerick, Plassy Technological Park, Limerick V94 T9PX, Ireland.
ACS Sustain Chem Eng. 2021 Feb 15;9(6):2515-2522. doi: 10.1021/acssuschemeng.0c08022. Epub 2021 Jan 22.
Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range of 100-160 μm were obtained. Varying lignin molecular structure played a key role in tailoring swelling and mechanical performance of these gels with organosolv-type lignin showing optimum properties due to its propensity for intermolecular cross-linking, achieving a compressive modulus around 11 kPa. Paracetamol was selected as a standard drug for release tests and its release rate was improved with the presence of lignin (50% more compared to pure cellulose hydrogels). This was attributed to a reduction in molecular interactions between paracetamol and cellulose. These results highlight the potential for the valorization of lignin as a platform for drug-release systems.
以木材（纤维素和木质素）为基础的水凝胶已成功制备，作为药物释放系统的平台。通过冷冻干燥调节前体溶液的粘弹性和交联行为，以制备具有高度多孔结构的水凝胶。获得了孔径在100-160μm范围内的水凝胶。不同的木质素分子结构在调节这些凝胶的溶胀和力学性能方面起着关键作用，有机溶剂型木质素由于其分子间交联的倾向而表现出最佳性能，其压缩模量达到约11 kPa。选择对乙酰氨基酚作为释放测试的标准药物，木质素的存在提高了其释放速率（与纯纤维素水凝胶相比提高了50%）。这归因于对乙酰氨基酚与纤维素之间分子相互作用的减少。这些结果突出了木质素作为药物释放系统平台增值利用的潜力。
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