Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
J Hum Nutr Diet. 2022 Aug;35(4):634-650. doi: 10.1111/jhn.13041. Epub 2022 Jun 16.
Previous studies have shown that the C allele of melanocortin 4 receptor (MC4R) rs17782313 and the Alternative Healthy Eating Index (AHEI) are separately associated with obesity. However, the present study aimed to investigate the interaction between MC4R rs17782313 variants and the AHEI and their association with central and general obesity indices, which has not been assessed previously.
In total, 291 women with body mass index (BMI) ≥ 25 kg m and aged 18-48 years enrolled in this cross-sectional study. All participants were assessed for body composition, anthropometric measures, dietary intake, and blood parameters. After obtaining data of dietary intake from the 147-item food frequency questionnaire, the AHEI was calculated. MC4R rs17782313 single-nucleotide polymorphisms were assessed using the polymerase chain reaction-restriction length polymorphism method.
After adjustment for age, energy intake, physical activity, marital status, and economic status, the interaction between MC4R rs17782313 and the AHEI was associated with hip circumference [β = -0.41, 95% confidence interval (CI) = -0.77 to -0.05, p = 0.02], BMI (β = -0.15, 95% CI = -0.29 to -0.02, p = 0.02), fat mass (kg) (β = -0.28, 95% CI = -0.56 to -0.01, p = 0.03), visceral fat area (β = -5.68, 95% CI = -9.55 to -1.80, p = 0.004). The other measures that appear to be suggestively related to this interaction (0.05 < p < 0.07) are waist circumference, waist-to-height ratio, trunk fat (%), trunk fat (kg), fat mass (%) and fat mass index.
The interaction between MC4R rs17782313 and the AHEI can be related to central and general obesity indices in overweight/obese women.
先前的研究表明，黑皮质素 4 受体 (MC4R) rs17782313 的 C 等位基因和替代健康饮食指数 (AHEI) 分别与肥胖有关。然而，本研究旨在探讨 MC4R rs17782313 变异与 AHEI 之间的相互作用及其与中心性和全身性肥胖指数的关系，这在以前尚未得到评估。
本横断面研究共纳入 291 名 BMI≥25kg/m2 且年龄在 18-48 岁的女性。所有参与者均进行了身体成分、人体测量学指标、饮食摄入和血液参数评估。从 147 项食物频率问卷中获得饮食摄入数据后，计算了 AHEI。采用聚合酶链反应-限制性长度多态性方法检测 MC4R rs17782313 单核苷酸多态性。
在调整年龄、能量摄入、身体活动、婚姻状况和经济状况后，MC4R rs17782313 与 AHEI 之间的相互作用与臀围[β=-0.41，95%置信区间 (CI)=-0.77 至-0.05，p=0.02]、BMI（β=-0.15，95%CI=-0.29 至-0.02，p=0.02）、脂肪量（kg）（β=-0.28，95%CI=-0.56 至-0.01，p=0.03）、内脏脂肪面积（β=-5.68，95%CI=-9.55 至-1.80，p=0.004）相关。其他似乎与这种相互作用相关的指标（0.05<p<0.07）包括腰围、腰高比、躯干脂肪（%）、躯干脂肪（kg）、脂肪量（%）和脂肪量指数。
MC4R rs17782313 与 AHEI 之间的相互作用可能与超重/肥胖女性的中心性和全身性肥胖指数有关。
