Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Quality Control Department, National Anti-Drug Laboratory Shaanxi Regional Center, Xianyang 712000, China.
J Asian Nat Prod Res. 2023 Feb;25(2):156-162. doi: 10.1080/10286020.2022.2077199. Epub 2022 May 26.
Two new sesquiterpenoids, flammupin A () and flammupin B (), along with two known compounds, enokipodin C () and 5,5'-dibuthoxy-2,2'-bifuran () were obtained from , an endophytic fungus isolated from the roots of Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC values ranged from 3.69 to 11.84 μM.
从 Maxim 根部分离出的一株内生真菌 中分离得到两个新的倍半萜类化合物flammupin A () 和 flammupin B ()，以及两个已知化合物 enokipodin C () 和 5,5'-二丁氧基-2,2'-联呋喃 ()。通过 HR-ESI-MS、NMR 和 ECD 分析相结合的方法确定了它们的结构。化合物 对 A549、HeLa 和 SMMC-7721 细胞表现出中等至较强的细胞毒性，IC 值范围为 3.69 至 11.84 μM。
